GATA3-Positive Adnexal Adenocarcinoma: Report of a Confusing Case with a Potential Pitfall of Leading to a Misdiagnosis of Urothelial Carcinoma and a Review of Published Work
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We describe a confusing case of GATA3-positive adnexal adenocarcinoma with a potential pitfall of leading to a misdiagnosis of urothelial carcinoma. A 62-year-old male presented with a subcutaneous nodule on the right lower abdomen around a scar from surgery for urothelial carcinoma in the right urinary tract, which had been resected 8 years previously. Histologically, atypical cells possessing ample cytoplasm and partial intracytoplasmic lumens were densely grouped in the subcutaneous expansive nodule and bilateral inguinal lymph nodes dissected. Decapitation secretion could not be seen. Neoplastic cells were positive for CK7, GATA3, and GCDFP15, and negative for CK5/6, CK20, p63, CD10, PAX8, HER-2, and uroplakin-Ⅱ. Neoplastic cells in the urothelium and the metastasized lung were positive for CK7, CK5/6, and GATA3, and negative for CK20, p63, GCDFP15, and TTF-1. A variable level of GATA3 expression in malignant tumors with apocrine and eccrine differentiation should be recognized by dermatologists.
Abstract
We describe a confusing case of GATA3-positive adnexal adenocarcinoma with a potential pitfall of leading to a misdiagnosis of urothelial carcinoma. A 62-year-old male presented with a subcutaneous nodule on the right lower abdomen around a scar from surgery for urothelial carcinoma in the right urinary tract, which had been resected 8 years previously. Histologically, atypical cells possessing ample cytoplasm and partial intracytoplasmic lumens were densely grouped in the subcutaneous expansive nodule and bilateral inguinal lymph nodes dissected. Decapitation secretion could not be seen. Neoplastic cells were positive for CK7, GATA3, and GCDFP15, and negative for CK5/6, CK20, p63, CD10, PAX8, HER-2, and uroplakin-Ⅱ. Neoplastic cells in the urothelium and the metastasized lung were positive for CK7, CK5/6, and GATA3, and negative for CK20, p63, GCDFP15, and TTF-1. A variable level of GATA3 expression in malignant tumors with apocrine and eccrine differentiation should be recognized by dermatologists.
참고문헌 (16)
- Massi D, "WHO classification of skin tumours", pp.155~156 (2018), International Agency for Research on Cancer
- Pardal J, "GATA3 and MYB expression in cutaneous adnexal neoplasms", Am J Dermatopathol, 39, pp.279~286 (2017)
- Higgins JP, "Placental S100(S100P)and GATA3 : markers for transitional epithelium and urothelial carcinoma discovered by complementary DNA microarray", Am J Surg Pathol, 31, pp.673~680 (2007)
- Miettinen M, "GATA3 : a multispecific but potentially useful marker in surgical pathology : a systematic analysis of 2500 epithelial and nonepithelial tumors", Am J Surg Pathol, 38, pp.13~22 (2014)
- Liu H, "Immunohistochemical evaluation of GATA3 expression in tumors and normal tissues : a useful immunomarker for breast and urothelial carcinomas", Am J Clin Pathol, 138, pp.57~64 (2012)
- Asch-Kendrick R, "The role of GATA3 in breast carcinomas : a review", Hum Pathol, 48, pp.37~47 (2016)
- Ordóñez NG, "Value of GATA3 immunostaining in the diagnosis of parathyroid tumors", Appl Immunohistochem Mol Morphol, 22, pp.756~761 (2014)
- So JS, "GATA3 expression in paragangliomas : a pitfall potentially leading to misdiagnosis of urothelial carcinoma", Mod Pathol, 26, pp.1365~1370 (2013)
- Banet N, "GATA-3 expression in trophoblastic tissues: an immunohistochemical study of 445 cases, including diagnostic utility", Am J Surg Pathol, 39, pp.101~108 (2015)
- Schwartz LE, "GATA3immunohistochemical expression in salivary gland neoplasms", Head Neck Pathol, 7, pp.311~315 (2013)
- Morbeck D, "GATA3 expression in primary vulvar Paget disease : a potential pitfall leading to misdiagnosis of pagetoid urothelial intraepithelial neoplasia", Histopathology, 70, pp.435~441 (2017)
- Zhao M, "GATA3 is a sensitive marker for primary genital extramammary paget disease : an immunohistochemical study of 72cases with comparison to gross cystic disease fluid protein 15", Diagn Pathol, 12, pp.51~ (2017)
- Mertens RB, "GATA3 expression in normal skin and in benign and malignant epidermal and cutaneous adnexal neoplasms", Am J Dermatopathol, 37, pp.885~891 (2015)
- Mentrikoski MJ, "Immunohistochemical distinction of primary sweat gland carcinoma and metastatic breast carcinoma: can it always be accomplished reliably?", Am J Clin Pathol, 143, pp.430~436 (2015)
- Chou YH, "Endocrine mucin-producing sweat gland carcinoma with GATA3 expression : report of two cases", Pathology, 49, pp.805~808 (2017)
- Llamas-Velasco M, "GATA3 staining in primary cutaneous apocrine cribriform carcinoma : usefulness to differentiate it from breast cancer metastasis", J Cutan Pathol, 45, pp.348~351 (2018)