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Atypical Porokeratosis Developing Following Bone Marrow Transplantation in a Patient with Myelodysplastic Syndrome

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초록

Porokeratosis is an abnormal disease of keratinization of epidermis. It is clinically characterized by margins covered with keratin layer and it typically has an atrophied macule with a protruded, circular form. Histopathologically, it shows the findings of cornoid lamella. Risk factors for its development include organ transplantation, long-term use of corticosteroids, immunocompromised status, including AIDS, and exposure to ultraviolet light. We herein report a case of atypical porokeratosis in a 38-year-old man who developed porokeratosis involving multiple sites following bone marrow transplantation for myelodysplastic syndrome. (Ann Dermatol 22(2) 206∼208, 2010)

Abstract

Porokeratosis is an abnormal disease of keratinization of epidermis. It is clinically characterized by margins covered with keratin layer and it typically has an atrophied macule with a protruded, circular form. Histopathologically, it shows the findings of cornoid lamella. Risk factors for its development include organ transplantation, long-term use of corticosteroids, immunocompromised status, including AIDS, and exposure to ultraviolet light. We herein report a case of atypical porokeratosis in a 38-year-old man who developed porokeratosis involving multiple sites following bone marrow transplantation for myelodysplastic syndrome. (Ann Dermatol 22(2) 206∼208, 2010)

참고문헌 (11)

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  7. Gilead L, "Immunosuppression-induced porokeratosis of Mibelli:complete regression of lesions upon cessation of immunosuppressive therapy", J Eur Acad Dermatol Venereol, 5, pp.170~172 (1995)
  8. Raychaudhuri SP, "Porokeratosis in immunosuppressed and nonimmunosuppressed patients", Int J Dermatol, 31, pp.781~782 (1992)
  9. Ghigliotti G, "Mibelli's porokeratosis after bone marrow transplantation", Ann Dermatol Venereol, 119, pp.968~970 (1992)
  10. Manganoni AM, "Involvement of epidermal Langerhans cells in porokeratosis of immunosuppressed renal transplant recipients", J Am Acad Dermatol, 21, pp.799~801 (1989)
  11. Anzai S, "Squamous cell carcinoma in a renal transplant recipient with linear porokeratosis", J Dermatol, 26, pp.244~247 (1999)

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