The Influence of Pregnancy and Menstruation on the Deterioration of Atopic Dermatitis Symptoms
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Background: Female patients with atopic dermatitis (AD)often experience cutaneous deterioration associated with their pregnancy or menstrual cycle. Objective: We wanted to determine the prevalence of symptom aggravation as related to pregnancy and the menstrual cycle in female patients with AD. Methods: One hundred female patients with AD were included in the study and interviews were performed. The total IgE level and the Eczema Area and Severity Index score of the patients were retrospectively reviewed. Results:Ninety seven patients replied the questionnaire, and among them, 23 patients had completed at least 1 pregnancy. Among the 23 women who experienced pregnancy, 14(61%) had noticed deterioration of their clinical symptoms during pregnancy. Of the 97 females, 31 (32%) patients had noticed deterioration of their AD as related to their menstrual cycle. For the patients who were sub-grouped as the intrinsic type of AD, the prevalence of symptom aggravation as related to pregnancy was significantly higher as compared to that of the extrinsic type of AD patients (p=0.048). Conclusion: Of the 97 patients, 45 (46%) females answered that they have experienced deterioration of AD during pregnancy or in relation to their menstrual cycle, and this suggests the relation of a hormonal influence on the clinical manifestations of AD. (Ann Dermatol 22(2) 180∼185, 2010)
Abstract
Background: Female patients with atopic dermatitis (AD)often experience cutaneous deterioration associated with their pregnancy or menstrual cycle. Objective: We wanted to determine the prevalence of symptom aggravation as related to pregnancy and the menstrual cycle in female patients with AD. Methods: One hundred female patients with AD were included in the study and interviews were performed. The total IgE level and the Eczema Area and Severity Index score of the patients were retrospectively reviewed. Results:Ninety seven patients replied the questionnaire, and among them, 23 patients had completed at least 1 pregnancy. Among the 23 women who experienced pregnancy, 14(61%) had noticed deterioration of their clinical symptoms during pregnancy. Of the 97 females, 31 (32%) patients had noticed deterioration of their AD as related to their menstrual cycle. For the patients who were sub-grouped as the intrinsic type of AD, the prevalence of symptom aggravation as related to pregnancy was significantly higher as compared to that of the extrinsic type of AD patients (p=0.048). Conclusion: Of the 97 patients, 45 (46%) females answered that they have experienced deterioration of AD during pregnancy or in relation to their menstrual cycle, and this suggests the relation of a hormonal influence on the clinical manifestations of AD. (Ann Dermatol 22(2) 180∼185, 2010)
참고문헌 (24)
- Montnemery P, "Prevalence of self-reported eczema in relation to living environment,socio-economic status and respiratory symptoms assessed in a questionnaire study", BMC Dermatol, 3, pp.4~ (2003)
- Folster-Holst R, "Low prevalence of the intrinsic form of atopic dermatitis among adult patients", Allergy, 61, pp.629~632 (2006)
- Ingordo V, "Results of atopy patch tests with house dust mites in adults with 'intrinsic' and 'extrinsic' atopic dermatitis", J Eur Acad Dermatol Venereol, 16, pp.450~454 (2002)
- Wuthrich B, "The atopic eczema", dermatitis syndrome.Epidemiology,natural course,and immunology of the IgE-associated("extrinsic")and the nonallergic("intrinsic")AEDS, 2003, pp.13, 1~5
- Kornizky Y, "Specific IgE antibodies to aeroallergens and food among Israelis", Ann Allergy Asthma Immunol, 83, pp.149~152 (1999)
- Chen W, "Gender difference,sex hormones,and immediate type hypersensitivity reactions", Allergy, 63, pp.1418~1427 (2008)
- Kemmett D, "The influence of the menstrual cycle and pregnancy on atopic dermatitis", Br J Dermatol, 125, pp.59~61 (1991)
- Weatherhead S, "Eczema in pregnancy", BMJ, 335, pp.152~154 (2007)
- Kiriyama K, "Premenstrual deterioration of skin symptoms in female patients with atopic dermatitis", Dermatology, 206, pp.110~112 (2003)
- Hanifin JM, "Diagnostic features of atopic dermatitis", Acta Derm Venerol, 92, pp.44~47 (1980)
- Ott H, "Total serum IgE as a parameter to differentiate between intrinsic and extrinsic atopic dermatitis in children", Acta Derm Venereol, 89, pp.257~261 (2009)
- Brunsting LA, "Atopic dermatitis(disseminated neurodermatitis)of young adults.Analysis of precipitating factors in one hundred and one cases and report of ten cases with associated juvenile cataract", Arch Derm Syphilol, 34, pp.935~957 (1936)
- Rajka G, "Essential aspects of atopic dermatitis" (1989), Springer-Verlag
- Hellerstrom S, "Studies of Besnier's prurigo(atopic dermatitis)", Acta Derm Venereol, 36, pp.11~22 (1956)
- Rajka G, "Prurigo Besnier(atopic dermatitis)with special reference to the role of allergic factors.III.The role of some factors in the course of the prurigo Besnier", Acta Derm Venereol, 41, pp.363~395 (1961)
- Garell DC, "Atopic dermatitis in females during adolescence", Am J Dis Child, 107, pp.350~355 (1964)
- Roth HL, "The natural history of atopic dermatitis.A 20-year follow-up study", Arch Dermatol, 89, pp.209~214 (1964)
- Wuthrich B, "Zur Immunopathologie der Neurodermatitis constitutionalis" (1975), Huber
- Saito S, "Quantitative analysis of peripheral blood Th0,Th1,Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia", Clin Exp Immunol, 117, pp.550~555 (1999)
- Ikeno N, "Studies on changes in serum estrone,estradiol,estriol,DHA-S,and cortisol and urinary estriol excretion", Nippon Sanka Fujinka Gakkai Zasshi, 37, pp.99~106 (1985)
- Daynes RA, "Regulation of murine lymphokine production in vivo.II.Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cells", Eur J Immunol, 20, pp.793~802 (1990)
- Suzuki T, "Dehydroepiandrosterone enhances IL2 production and cytotoxic effector function of human T cells", Clin Immunol Immunopathol, 61, pp.202~211 (1991)
- Agner T, "Menstrual cycle and skin reactivity", J Am Acad Dermatol, 24, pp.566~570 (1991)
- Alexander S, "Patch testing and menstruation", Lancet, 2, pp.751~ (1988)