Kasabach-Merritt Syndrome Arising from Tufted Angioma Successfully Treated with Systemic Corticosteroid
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We report a case of Kasabach-Merritt syndrome arising from a tufted angioma successfully treated with systemic corticosteroid. A 2-month-old male infant presented with a palm-sized, erythematous induration on his left pubis. The lesion was diagnosed as tufted angioma histopathologically. After 1 month, the lesion suddenly expanded to the abdomen and scrotum. Initial laboratory tests were consistent with consumptive coagulopathy. He was diagnosed with Kasabach-Merritt syndrome and treated with intravenous dexamethasone at 0.32 mg/kg/day (equivalent to prednisolone 2.0 mg/kg/day). Two days after initiating the treatment,his platelet counts recovered and the lesion ceased to expand. Steroid therapy was converted to oral prednisolone and the dosage was subsequently tapered, and the lesion gradually involuted with no signs of recurrence for a year. (Ann Dermatol 22(4) 426∼430, 2010)
Abstract
We report a case of Kasabach-Merritt syndrome arising from a tufted angioma successfully treated with systemic corticosteroid. A 2-month-old male infant presented with a palm-sized, erythematous induration on his left pubis. The lesion was diagnosed as tufted angioma histopathologically. After 1 month, the lesion suddenly expanded to the abdomen and scrotum. Initial laboratory tests were consistent with consumptive coagulopathy. He was diagnosed with Kasabach-Merritt syndrome and treated with intravenous dexamethasone at 0.32 mg/kg/day (equivalent to prednisolone 2.0 mg/kg/day). Two days after initiating the treatment,his platelet counts recovered and the lesion ceased to expand. Steroid therapy was converted to oral prednisolone and the dosage was subsequently tapered, and the lesion gradually involuted with no signs of recurrence for a year. (Ann Dermatol 22(4) 426∼430, 2010)
참고문헌 (19)
- Kasabach HH, "Capillary hemangioma with extensive purpura:report of a case", Am J Dis Child, 59, pp.1063~1070 (1940)
- Alvarez-Mendoza A, "Histopathology of vascular lesions found in Kasabach-Merritt syndrome:review based on 13 cases", Pediatr Dev Pathol, 3, pp.556~560 (2000)
- Kim SH, "Clinical and histopathologic study on tufted angioma", Korean J Dermatol, 38, pp.72~78 (2000)
- Ishikawa K, "The spontaneous regression of tufted angioma.A case of regression after two recurrences and a review of 27 cases reported in the literature", Dermatology, 210, pp.346~348 (2005)
- Hesselmann S, "Case report:Kasabach-Merritt syndrome:a review of the therapeutic options and a case report of successful treatment with radiotherapy and interferon alpha", Br J Radiol, 75, pp.180~184 (2002)
- Shin HY, "Stepwise multimodal approach in the treatment of Kasabach-Merritt syndrome", Pediatr Int, 42, pp.620~624 (2000)
- Wananukul S, "Treatment of Kasabach-Merritt syndrome:a stepwise regimen of prednisolone,dipyridamole,and interferon", Int J Dermatol, 42, pp.741~748 (2003)
- Rodriguez V, "Kasabachmerritt phenomenon:case series and retrospective review of the mayo clinic experience", J Pediatr Hematol Oncol, 31, pp.522~526 (2009)
- Martins AG, "Hemangioma and thrombocytopenia", J Pediatr Surg, 5, pp.641~648 (1970)
- Enjolras O, "Residual lesions after Kasabach-Merritt phenomenon in 41 patients", J Am Acad Dermatol, 42, pp.225~235 (2000)
- Chu CY, "Transformation between Kaposiform hemangioendothelioma and tufted angioma", Dermatology, 206, pp.334~337 (2003)
- Esterly NB, "Kasabach-Merritt syndrome in infants", J Am Acad Dermatol, 8, pp.504~513 (1983)
- Karaböcüoğlu M, "Development of Kasabach-Merritt syndrome following needle aspiration of a hemangioma", Pediatr Emerg Care, 8, pp.218~220 (1992)
- Jona JZ, "Disseminated intravascular coagulation after excision of giant hemangioma", Am J Surg, 127, pp.588~592 (1974)
- Hall GW, "Kasabach-Merritt syndrome:pathogenesis and management", Br J Haematol, 112, pp.851~862 (2001)
- Enjolras O, "Management of alarming hemangiomas in infancy:a review of 25 cases", Pediatrics, 85, pp.491~498 (1990)
- Sadan N, "Treatment of hemangiomas of infants with high doses of prednisone", J Pediatr, 128, pp.141~146 (1996)
- Ozsoylu S, "High dose intravenous methylprednisolone for Kassabach-Merritt syndrome", Eur J Pediatr, 148, pp.403~405 (1989)
- Uysal KM, "High-dose oral methylprednisolone therapy in childhood hemangiomas", Pediatr Hematol Oncol, 18, pp.335~341 (2001)