마황(에페드라) 함유 한약 복용 후 발생한 근육병증
Myopathy Following Ingestion of Ma-huang (Ephedra)-based Herbal Remedy
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Ma-huang (Ephedra sinica) is a herb that exhibits sympathomimetic activity. We report a patient with acquired myopathy following ingestion of a Ma-huang-based herbal remedy for 6 months. A 50-year-old woman was admitted for progressive muscular weakness. An electrodiagnostic study and muscle biopsy sampling revealed generalized active myopathy with nonspecific inflammation. It appears that Ma-huang, along with Raynaud’s phenomenon and pericardial effusion, may be a causative agent of myopathy. As such, attention should be paid to the possibility that herbal medication with Ma-huang can result in myopathy.
Abstract
Ma-huang (Ephedra sinica) is a herb that exhibits sympathomimetic activity. We report a patient with acquired myopathy following ingestion of a Ma-huang-based herbal remedy for 6 months. A 50-year-old woman was admitted for progressive muscular weakness. An electrodiagnostic study and muscle biopsy sampling revealed generalized active myopathy with nonspecific inflammation. It appears that Ma-huang, along with Raynaud’s phenomenon and pericardial effusion, may be a causative agent of myopathy. As such, attention should be paid to the possibility that herbal medication with Ma-huang can result in myopathy.
참고문헌 (10)
- Abourashed EA, "Ephedra in perspective--a current review", Phytother Res, 17, pp.703~712 (2003)
- Dhar R, "Cardiovascular toxicities of performance-enhancing substances in sports", Mayo Clin Proc, 80, pp.1307~1315 (2005)
- Burke J, "A case of severe exercise-induced rhabdomyolysis associated with a weight-loss dietary supplement", Mil Med, 172, pp.656~658 (2007)
- Zaacks SM, "Hypersensitivity myocarditis associated with ephedra use", J Toxicol Clin Toxicol, 37, pp.485~489 (1999)
- Stahl CE, "No pain, no gain--exercise-induced rhabdomyolysis associated with the performance enhancer herbal supplement ephedra", Med Sci Monit, 12, pp.CS81~CS84 (2006)
- Hewer E, "Myopathology of non-infectious inflammatory myopathies - the current status", Pathol Res Pract, 204, pp.609~623 (2008)
- Jain A, "Major histocompatibility complex class I and II detection as a diagnostic tool in idiopathic inflammatory myopathies", Arch Pathol Lab Med, 131, pp.1070~1076 (2007)
- Guis S, "Drug-induced and toxic myopathies", Best Pract Res Clin Rheumatol, 17, pp.877~907 (2003)
- Needham M, "Progressive myopathy with up-regulation of MHC-I associated with statin therapy", Neuromuscul Disord, 17, pp.194~200 (2007)
- Sordet C, "Contribution of autoantibodies to the diagnosis and nosology of inflammatory muscle disease", Joint Bone Spine, 73, pp.646~654 (2006)