안구증상으로 발현한 Lambert-Eaton Myasthenic Syndrome (LEMS)
Lambert-Eaton Myasthenic Syndrome (LEMS) Presented With Ocular Symptoms
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초록
Lambert-Eaton myasthenic syndrome (LEMS) is characterized clinically by fluctuating muscular weakness; presentation with ocular symptoms is unusual. A 60-year-old man had developed diplopia and ptosis 2 years previously. The findings of a neurologic examination were normal except for bilateral ptosis and ophthalmoplegia. The amplitude of compound muscle action potentials recorded on the abductor digiti minimi increased (by more than 500%) during 50-Hz stimulation. This case demonstrates that LEMS should be included in the differential diagnosis of myasthenic symptom confined to the ocular muscles.
Abstract
Lambert-Eaton myasthenic syndrome (LEMS) is characterized clinically by fluctuating muscular weakness; presentation with ocular symptoms is unusual. A 60-year-old man had developed diplopia and ptosis 2 years previously. The findings of a neurologic examination were normal except for bilateral ptosis and ophthalmoplegia. The amplitude of compound muscle action potentials recorded on the abductor digiti minimi increased (by more than 500%) during 50-Hz stimulation. This case demonstrates that LEMS should be included in the differential diagnosis of myasthenic symptom confined to the ocular muscles.
참고문헌 (9)
- Seneviratue U, "Lambert-Eaton myasthenic syndrome", Postgrad Med J, 75, pp.516~520 (1999)
- O’Neill JH, "The Lambert-Eaton myasthenic syndrome. A review of 50 cases", Brain, 111, pp.577~596 (1988)
- Wirtz PW, "Difference in distribution of muscle weakness between myasthenia gravis and the Lambert-Eaton myasthenic syndrome", J Neurol Neurosurg Psychiatry, 73, pp.766~768 (2002)
- Rudnicki SA, "Lambert-Eaton myasthenic syndrome with pure ocular weakness", Neurology, 68, pp.1863~1864 (2007)
- Burns TM, "Oculobulbar involvement is typical with Lambert-Eaton myasthenic syndrome", Ann Neurol, 53, pp.270~227 (2003)
- Ropper AH, "Adams and Victor’s principles of neurology. 9th ed", pp.1417~1418 (2009), Mc Graw Hill
- Pascuzzi RM, "Myasthenia gravis and Lambert-Eaton syndrome", Ther Apher, 6, pp.57~68 (2002)
- Vedeler CA, "Management of paraneoplastic neurological syndromes: report of an EFNS Task Force", Eur J Neurol, 13, pp.682~690 (2006)
- Titulaer MJ, "Screening for small-cell lung cancer: a follow-up study of patients with Lambert-Eaton myasthenic syndrome", J Clin Oncol, 26, pp.4276~4281 (2008)