Neonatal Erythema Multiforme: A Case Report
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Erythema multiforme (EM) is an extremely rare condition in infancy. To the best of our knowledge, there have been only three cases of neonatal EM described in the literature, and no such cases have been reported in Korea. A preterm neonate born at 35 weeks and six days of gestation presented with multiple annular erythematous patches with a targetoid shape over his entire body at 36 days of age (corrected age of 7 days). He had no systemic symptoms except for transient mild fever. No triggering factor except for hepatitis B and BCG vaccination was found. Neutropenia was noted upon laboratory analysis. Skin biopsy specimens showed findings suggestive of erythema multiforme. The skin lesions improved rapidly upon administration of intravenous methylprednisolone; however, neutropenia continued for a much longer period. The significance of neutropenia with respect to the development of EM was not clarified. There has been no recurrence of skin lesions over a one-year follow-up period. (Ann Dermatol 23(3) 382∼385, 2011)
Abstract
Erythema multiforme (EM) is an extremely rare condition in infancy. To the best of our knowledge, there have been only three cases of neonatal EM described in the literature, and no such cases have been reported in Korea. A preterm neonate born at 35 weeks and six days of gestation presented with multiple annular erythematous patches with a targetoid shape over his entire body at 36 days of age (corrected age of 7 days). He had no systemic symptoms except for transient mild fever. No triggering factor except for hepatitis B and BCG vaccination was found. Neutropenia was noted upon laboratory analysis. Skin biopsy specimens showed findings suggestive of erythema multiforme. The skin lesions improved rapidly upon administration of intravenous methylprednisolone; however, neutropenia continued for a much longer period. The significance of neutropenia with respect to the development of EM was not clarified. There has been no recurrence of skin lesions over a one-year follow-up period. (Ann Dermatol 23(3) 382∼385, 2011)
참고문헌 (23)
- Huff JC, "Erythema multiforme: a critical review of characteristics, diagnostic criteria, and causes", J Am Acad Dermatol, 8, pp.763~775 (1983)
- Edmond BJ, "Erythema multiforme", Pediatr Clin North Am, 30, pp.631~640 (1983)
- Weston WL, "Herpes simplex virus-associated erythema multiforme in prepubertal children", Arch Pediatr Adolesc Med, 151, pp.1014~1016 (1997)
- Brice SL, "Erythema multiforme", Curr Probl Dermatol, 2, pp.3~26 (1990)
- Dikland WJ, "Erythema multiforme in childhood and early infancy", Pediatr Dermatol, 3, pp.135~139 (1986)
- Johnston GA, "Neonatal erythema multiforme major", Clin Exp Dermatol, 27, pp.661~664 (2002)
- Torrelo A, "Erythema multiforme in a neonate", J Am Acad Dermatol, 48(5), pp.78~79 (2003)
- Custer JW, "The harriet lane handbook. 18th ed", pp.360~ (2008), Philadelphia: Mosby
- Ashkenazi S, "Erythema multiforme as a single manifestation of cow’s milk intolerance", Acta Paediatr, 81, pp.729~730 (1992)
- Nanda S, "Erythema multiforme in a 9-day-old neonate", Pediatr Dermatol, 20, pp.454~455 (2003)
- Wine E, "Infantile erythema multiforme following hepatitis B vaccine", Acta Paediatr, 95, pp.890~891 (2006)
- Korting HC, "Erythema multiforme and dermatitis seborrhoides infantum as concomitant id-reactions to widespread candidosis in a suckling", Mycoses, 34, pp.415~417 (1991)
- Kliegman RM, "Nelson textbook of pediatrics. 18th ed", pp.2744~ (2007), Philadelphia: WB Saunders
- Dostrovsky A, "Dermatological complications of BCG vaccination", Br J Dermatol, 75, pp.181~192 (1963)
- Dogliotti M, "Erythema multiforme--an unusual reaction to BCG vaccination", S Afr Med J, 57, pp.332~334 (1980)
- Tschen EH, "Erythema multiforme as a complication of BCG scarification technique", Arch Dermatol, 115, pp.614~615 (1979)
- Baley JE, "Neonatal neutropenia. Clinical manifestations, cause, and outcome", Am J Dis Child, 142, pp.1161~1166 (1988)
- Funke A, "Frequency, natural course, and outcome of neonatal neutropenia", Pediatircs, 106, pp.45~51 (2000)
- James RM, "The investigation and management of chronic neutropenia in children", Arch Dis Child, 91, pp.852~858 (2006)
- Weston WL, "Steroids in erythema multiforme (EM)", Pediatr Dermatol, 17, pp.75~83 (2000)
- Prendiville JS, "Erythema multiforme and steroids", Pediatr Dermatol, 17, pp.75~83 (2000)
- Renfro L, "Controversy: are systemic steroids indicated in the treatment of erythema multiforme", Pediatr Dermatol, 6, pp.43~50 (1989)
- Rasmussen JE, "Erythema multiforme in children. Response to treatment with systemic corticosteroids", Br J Dermatol, 95, pp.181~186 (1976)