구음장애와 보행장애로 나타난 두개내 랑게르한스조직구증
Intracranial Langerhans Cell Histiocytosis Presenting with Dysarthria and Gait Disturbance
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초록
Langerhans cell histiocytosis (LCH) is a rare disease of the monocyte-macrophage system involving clonal proliferation of Langerhans cells. Central nervous system (CNS) involvement of LCH occurs in 10-57% of all LCH cases. This disease is known to present in two ways in the CNS: intracranial tumorous lesions or intracranial nontumorous lesions (neurodegeneration). We report here an LCH patient who developed gait disturbance and dysarthria due to neurodegenerative lesions associated with LCH.
Abstract
Langerhans cell histiocytosis (LCH) is a rare disease of the monocyte-macrophage system involving clonal proliferation of Langerhans cells. Central nervous system (CNS) involvement of LCH occurs in 10-57% of all LCH cases. This disease is known to present in two ways in the CNS: intracranial tumorous lesions or intracranial nontumorous lesions (neurodegeneration). We report here an LCH patient who developed gait disturbance and dysarthria due to neurodegenerative lesions associated with LCH.
참고문헌 (10)
- Abla O, "Langerhans cell histiocytosis: Current concepts and treatments", Cancer Treat Rev, 36, pp.354~359 (2010)
- Ng-Cheng-Hin B, "Langerhans cell histiocytosis: old disease new treatment", QJM, 104, pp.89~96 (2011)
- Laurencikas E, "Incidence and pattern of radiological central nervous system Langerhans cell histiocytosis in children: A population based study", Pediatr Blood Cancer, 56, pp.250~257 (2011)
- Bernstrand C, "Long-term follow-up of Langerhans cell histiocytosis: 39 years’ experience at a single centre", Acta Paediatr, 94, pp.1073~1084 (2005)
- 강규식, "중추신경계 Langerhans 조직구 증식증 1예:뇌 MRI 소견 및 임상 경과", 대한신경과학회지, 20(3), pp.279~282 (2002), 대한신경과학회
- Barthez MA, "Langerhans cell histiocytosis and the central nervous system in childhood: evolution and prognostic factors. Results of a collaborative study", J Chikd Neurol, 15, pp.150~156 (2000)
- Schmitt S, "Pituitary stalk thickening with diabetes insipidus preceding typical manifestations of Langerhans cell histiocytosis in children", Eur J Pediatr, 152, pp.399~401 (1993)
- Perry VH, "Central nervous system involvement in Langerhans cell histiocytosis: the importance of long term follow-up", Pediatr Blood Cancer, 56, pp.175~176 (2011)
- Grois N, "CNS LCH Co-operative Group. Neuropathology of CNS disease in Langerhans cell histiocytosis", Brain, 128, pp.829~838 (2005)
- Grois N, "Central nervous system disease in Langerhans cell histiocytosis", J Pediatr, 156, pp.873~881 (2010)