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Apocrine Carcinoma of the Groin Possibly Associated with Extramammary Paget’s Disease

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초록

Apocrine carcinoma is a rare malignancy with invasive potential. It presents as painless, slow-growing, firm or cystic, red nodules with focal ulcerations. The tumor is capable of hematogenous dissemination to the liver, lungs,and bone as well as lymphatic spread. In addition, apocrine carcinomas cause intra-epidemial pagetoid spread. We report a case of an apocrine carcinoma related with extensive extramammary Paget's disease (EMPD). The relationship between apocrine carcinoma and EMPD remains to be understood. Co-existing cases with apocrine carcinoma and EMPD are discussed to better understand the relationship between these two malignant apocrine tumors. (Ann Dermatol 23(4) 519∼522, 2011)

Abstract

Apocrine carcinoma is a rare malignancy with invasive potential. It presents as painless, slow-growing, firm or cystic, red nodules with focal ulcerations. The tumor is capable of hematogenous dissemination to the liver, lungs,and bone as well as lymphatic spread. In addition, apocrine carcinomas cause intra-epidemial pagetoid spread. We report a case of an apocrine carcinoma related with extensive extramammary Paget's disease (EMPD). The relationship between apocrine carcinoma and EMPD remains to be understood. Co-existing cases with apocrine carcinoma and EMPD are discussed to better understand the relationship between these two malignant apocrine tumors. (Ann Dermatol 23(4) 519∼522, 2011)

참고문헌 (8)

  1. David W, "Tumors of cutaneous appendages. In Weedon's skin pathology. 3rd ed", pp.757~807 (2010), Oxford: Elsevier Ltd
  2. Robson A, "Primary cutaneous apocrine carcinoma: a clinico-pathologic analysis of 24 cases", Am J Surg Pathol, 32, pp.682~690 (2008)
  3. Hernandez JM, "Infiltrating apocrine adenocarcinoma with extramammary pagetoid spread", Am Surg, 73, pp.307~309 (2007)
  4. Pascual JC, "Extramammary Paget's disease of the groin with underlying carcinoma and fatal outcome", Clin Exp Dermatol, 33, pp.595~598 (2008)
  5. Bowling JC, "Spontaneous regression of extramammary Paget's disease after excision of primary apocrine carcinoma, in an immunosuppressed patient", Br J Dermatol, 153, pp.676~677 (2005)
  6. Mazoujian G, "Extramammary Paget's disease--evidence for an apocrine origin. An immunoperoxidase study of gross cystic disease fluid protein-15, carcinoembryonic antigen, and keratin proteins", Am J Surg Pathol, 8, pp.43~50 (1984)
  7. Miyamoto T, "Differential expression of mucin core proteins and keratins in apocrine carcinoma, extramammary Paget's disease and apocrine nevus", J Cutan Pathol, 36, pp.529~534 (2009)
  8. Krause W, "Genital Paget's disease in a man", Eur J Dermatol, 16, pp.75~78 (2006)

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