Levetiracetam을 복용하는 뇌전증 환자에서 개똥쑥에 의한 발작유발
Seizure Induction by Artemisia Annua in an Epilepsy Patient Taking Levetiracetam
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초록
Artemisia annua is a wormwood. Because it may induce Cytochrome P450 2C19 enzyme, Artemisia annua may have an influence on antiepileptic drugs which are substrates for the enzyme. This influence may negatively affect seizure control of epilepsy patient. We present a patient whose seizures were induced by Artemisia annua, despite he was taking levetiracetam which is not a substrate for the hepatic enzyme. Therefore there would be another mechanism of seizure induction of Artemisia annua besides hepatic metabolism.
Abstract
Artemisia annua is a wormwood. Because it may induce Cytochrome P450 2C19 enzyme, Artemisia annua may have an influence on antiepileptic drugs which are substrates for the enzyme. This influence may negatively affect seizure control of epilepsy patient. We present a patient whose seizures were induced by Artemisia annua, despite he was taking levetiracetam which is not a substrate for the hepatic enzyme. Therefore there would be another mechanism of seizure induction of Artemisia annua besides hepatic metabolism.
참고문헌 (10)
- Klayman DL, "Qinghaosu (artemisinin): an antimalarial drug from China", Science, 228, pp.1049~1055 (1985)
- Singh N, "Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells", Life Sci, 70, pp.49~56 (2001)
- Skyles AJ, "Alternative therapies. Wormwood", Am J Health Syst Pharm, 61, pp.239~242 (2004)
- Sukhija M, "Effects of artemisinin, artemether, and arteether on the pharmacokinetics of phenytoin", Methods Find Exp Clin Pharmacol, 28, pp.89~94 (2006)
- Wyllie E, "Treatment of epilepsy", pp.635~636 (2011), Williams & Wilkins
- 류지현, "개똥쑥의 항산화 및 항암활성과 기능성 물질의 탐색", 한국식품영양과학회지, 40(4), pp.509~516 (2011), 한국식품영양과학회
- Svensson US, "Artemisinin induces omeprazole metabolism in human beings", Clin Pharmacol Ther, 64, pp.160~167 (1998)
- Perazzo FF, "Central properties of the essential oil and the crude ethanol extract from aerial parts of Artemisia annua L", Pharmacol Res, 48, pp.497~502 (2003)
- Hold KM, "Alpha-thujone (the active component of absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification", Proc Natl Acad Sci U S A, 97, pp.3826~3831 (2000)
- Treiman DM, "GABAergic mechanisms in epilepsy", Epilepsia, 42(Suppl 3), pp.8~12 (2001)