Pilot Study of the Efficacy of 578 nm Copper Bromide Laser Combined with Intralesional Corticosteroid Injection for Treatment of Keloids and Hypertrophic Scars
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Background: Treatments including intralesional corticosteroidinjection, pressure therapy, cryotherapy, and various lasertherapies have had limited success for keloids and hypertrophicscars. Objective: This trial evaluated the efficacy of acombination of 578 nm copper bromide laser and the moretraditional intralesional corticosteroid injection for thetreatment of keloids and hypertrophic scars with respect toscar color. Methods: Keloids or hypertrophic scars of 12Korean patients were treated five times by the combinedtreatment at 4-week intervals. Clinical improvement wasassessed by the physicians’ global assessment (PGA) comparingpre- and post-treatment photographs, as well as 4weeks after the last treatment. Erythema intensity wasquantified using a mexameter. Results: Most scars showedsignificant clinical improvement in PGA and decreasederythema intensity after 5 treatments. All patients showedimprovements in symptoms like pruritus. Conclusion: Thecombined treatment is effective for keloids and hypertrophicscars, especially when the telangiectatic portion of the scarsis prominent. The adjunctive use of 578 nm copper bromidelaser decreased the telangiectatic side effects of an intralesionalcorticosteroid injection by reducing the vascularcomponents of scars.
Abstract
Background: Treatments including intralesional corticosteroidinjection, pressure therapy, cryotherapy, and various lasertherapies have had limited success for keloids and hypertrophicscars. Objective: This trial evaluated the efficacy of acombination of 578 nm copper bromide laser and the moretraditional intralesional corticosteroid injection for thetreatment of keloids and hypertrophic scars with respect toscar color. Methods: Keloids or hypertrophic scars of 12Korean patients were treated five times by the combinedtreatment at 4-week intervals. Clinical improvement wasassessed by the physicians’ global assessment (PGA) comparingpre- and post-treatment photographs, as well as 4weeks after the last treatment. Erythema intensity wasquantified using a mexameter. Results: Most scars showedsignificant clinical improvement in PGA and decreasederythema intensity after 5 treatments. All patients showedimprovements in symptoms like pruritus. Conclusion: Thecombined treatment is effective for keloids and hypertrophicscars, especially when the telangiectatic portion of the scarsis prominent. The adjunctive use of 578 nm copper bromidelaser decreased the telangiectatic side effects of an intralesionalcorticosteroid injection by reducing the vascularcomponents of scars.
참고문헌 (23)
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