The Efficacy, Longevity, and Safety of Combined Radiofrequency Treatment and Hyaluronic Acid Filler for Skin Rejuvenation
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Background: Recent advances in hyaluronic acid (HA) fillersand radiofrequency (RF) devices have been made in thecontext of skin rejuvenation and cosmetic surgery. Moreover,combination regimens with both techniques are currentlybeing developed. Objective: The present study wasdesigned to examine the clinical and histologic effects of anew needle that incorporates an RF device for HA injections. Methods: A new intradermal needle RF device (INNOfill;Pacific Pharma, Korea) was assessed in the present study. Inthe animal arm, procollagen production was measured byusing enzyme-linked immunosorbent assay, the filler volumewas quantified by incorporating a dye with filler, andthe filler distribution was assessed through the changes intissue structure. In the human arm, the efficacy of the combinationregimen was assessed by using the wrinkle severityrating scale (WSRS). Results: In the animal study, RF treatmentincreased procollagen production in a time-dependentfashion. The total volume was significantly increased withthe RF treatment when compared with the filler injectionsalone, and lasted for up to 7 weeks after treatment. Additionally,the filler distribution was reduced in animals treatedwith RF when compared with the untreated group. In thehuman study, the nasolabial folds of subjects treated with RFbefore filler injections exhibited a significantly greaterchange in the WSRS score from baseline when comparedwith the nasolabial folds treated with filler injections alone. Conclusion: A new device incorporating RF treatment beforeHA filler injection may represent a biocompatible andlong-lasting advance in skin rejuvenation.
Abstract
Background: Recent advances in hyaluronic acid (HA) fillersand radiofrequency (RF) devices have been made in thecontext of skin rejuvenation and cosmetic surgery. Moreover,combination regimens with both techniques are currentlybeing developed. Objective: The present study wasdesigned to examine the clinical and histologic effects of anew needle that incorporates an RF device for HA injections. Methods: A new intradermal needle RF device (INNOfill;Pacific Pharma, Korea) was assessed in the present study. Inthe animal arm, procollagen production was measured byusing enzyme-linked immunosorbent assay, the filler volumewas quantified by incorporating a dye with filler, andthe filler distribution was assessed through the changes intissue structure. In the human arm, the efficacy of the combinationregimen was assessed by using the wrinkle severityrating scale (WSRS). Results: In the animal study, RF treatmentincreased procollagen production in a time-dependentfashion. The total volume was significantly increased withthe RF treatment when compared with the filler injectionsalone, and lasted for up to 7 weeks after treatment. Additionally,the filler distribution was reduced in animals treatedwith RF when compared with the untreated group. In thehuman study, the nasolabial folds of subjects treated with RFbefore filler injections exhibited a significantly greaterchange in the WSRS score from baseline when comparedwith the nasolabial folds treated with filler injections alone. Conclusion: A new device incorporating RF treatment beforeHA filler injection may represent a biocompatible andlong-lasting advance in skin rejuvenation.
참고문헌 (17)
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