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카르복시말토오스철 정맥 주사 후 발생한 아나필락시스

Anaphylaxis to Intravenous Ferric Carboxymaltose

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초록

The efficacy and the adverse effects of intravenous iron formulas have been well established. However, there are few reports of anaphylaxis of ferric carboxymaltose (FCM). A man received intravenous FCM for the treatment of restless legs syndrome. The FCM gave rise to angioedema, urticaria, chest tightness, sinus tachycardia, and hypotension. In the end, epinephrine and dexamethasone resolved the symptoms. The findings were consistent with anaphylactic hypersensitivity reaction from FCM. We need to be careful when we administer FCM in clinics.

Abstract

The efficacy and the adverse effects of intravenous iron formulas have been well established. However, there are few reports of anaphylaxis of ferric carboxymaltose (FCM). A man received intravenous FCM for the treatment of restless legs syndrome. The FCM gave rise to angioedema, urticaria, chest tightness, sinus tachycardia, and hypotension. In the end, epinephrine and dexamethasone resolved the symptoms. The findings were consistent with anaphylactic hypersensitivity reaction from FCM. We need to be careful when we administer FCM in clinics.

참고문헌 (10)

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  6. Roger SD, "Safety of intravenous ferric carboxymaltose versus oral iron in patients with nondialysis-dependent CKD: an analysis of the 1-year FIND-CKD trial", Nephrol Dial Transplant, 32, pp.1530~1539 (2017)[DOI]
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  8. Szebeni J, "Hypersensitivity to intravenous iron: classification, terminology, mechanisms and management", Br J Pharmacol, 172, pp.5025~5036 (2015)[DOI]
  9. Bircher AJ, "Hypersensitivity from intravenous iron products", Immunol Allergy Clin North Am, 34, pp.707~723 (2014)[DOI]
  10. Samant SA, "Anaphylaxis: diagnostic criteria and epidemiology", Allergy Asthma Proc, 34, pp.115~119 (2013)[DOI]

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