Erythrodermic Psoriasis Treated with Golimumab: A Case Report
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Erythrodermic psoriasis (EP) is a very severe variant of psoriasis whose management poses a challenge to physicians, as currently available therapies often provide unsatisfactory results. Many biologics have been used to treat chronic plaque psoriasis, the most common form of psoriasis; however, their effectiveness for EP is poorly understood. A recently developed biologic, golimumab, has been extensively studied for the treatment of moderate-to-severe active rheumatoid arthritis, psoriatic arthritis, active ankylosing spondylitis, and chronic plaque psoriasis. However, no clinical trials have been performed for EP. Here, we report the case of a 32-year-old man who presented with severe psoriasis that previously failed to respond satisfactorily to methotrexate, cyclosporine, retinoid, narrow-band ultraviolet B phototherapy, and topical agents (i.e., steroids and calcipotriol). Skin lesions worsened progressively and developed into erythroderma. Psoriatic arthritis was also detected. Conventional therapies lacked efficacy. Therefore, we administered golimumab 50 mg. The skin lesions improved significantly according to the Psoriasis Area and Severity Index score after the first administration; lesions improved further throughout the treatment course. Although additional studies are required to fully evaluate the efficacy and safety of golimumab, this agent may be an alternative treatment strategy for some patients with recalcitrant EP.
Abstract
Erythrodermic psoriasis (EP) is a very severe variant of psoriasis whose management poses a challenge to physicians, as currently available therapies often provide unsatisfactory results. Many biologics have been used to treat chronic plaque psoriasis, the most common form of psoriasis; however, their effectiveness for EP is poorly understood. A recently developed biologic, golimumab, has been extensively studied for the treatment of moderate-to-severe active rheumatoid arthritis, psoriatic arthritis, active ankylosing spondylitis, and chronic plaque psoriasis. However, no clinical trials have been performed for EP. Here, we report the case of a 32-year-old man who presented with severe psoriasis that previously failed to respond satisfactorily to methotrexate, cyclosporine, retinoid, narrow-band ultraviolet B phototherapy, and topical agents (i.e., steroids and calcipotriol). Skin lesions worsened progressively and developed into erythroderma. Psoriatic arthritis was also detected. Conventional therapies lacked efficacy. Therefore, we administered golimumab 50 mg. The skin lesions improved significantly according to the Psoriasis Area and Severity Index score after the first administration; lesions improved further throughout the treatment course. Although additional studies are required to fully evaluate the efficacy and safety of golimumab, this agent may be an alternative treatment strategy for some patients with recalcitrant EP.
참고문헌 (16)
- Esposito M, "Treatment of erythrodermic psoriasis with etanercept", Br J Dermatol, 155, pp.156~159 (2006)
- Boyce EG, "Golimumab: review of the efficacy and tolerability of a recently approved tumor necrosis factor-α inhibitor", Clin Ther, 32, pp.1681~1703 (2010)
- Boyd AS, "Erythrodermic psoriasis. Precipitating factors, course, and prognosis in 50 patients", J Am Acad Dermatol, 21, pp.985~991 (1989)
- Jalal O, "Severe psoriasis: 160 cases", Ann Dermatol Venereol, 132, pp.126~128 (2005)
- Marks J, "Psoriasis: proceedings of the International Symposium Stanford University", pp.89~98 (1971), Stanford University Press
- Heikkilä H, "Infliximab combined with methotrexate as long-term treatment for erythrodermic psoriasis", Arch Dermatol, 141, pp.1607~1610 (2005)
- Poulalhon N, "A follow-up study in 28 patients treated with infliximab for severe recalcitrant psoriasis: evidence for efficacy and high incidence of biological autoimmunity", Br J Dermatol, 156, pp.329~336 (2007)
- Takahashi MD, "Infliximab, as sole or combined therapy, induces rapid clearing of erythrodermic psoriasis", Br J Dermatol, 157, pp.828~831 (2007)
- Richetta AG, "Treatment of erythrodermic psoriasis in HCV＋ patient with adalimumab", Dermatol Ther, 22(Suppl 1), pp.S16~S18 (2009)
- Santos-Juanes J, "Ustekinumab induces rapid clearing of erythrodermic psoriasis after failure of antitumour necrosis factor therapies", Br J Dermatol, 162, pp.1144~1146 (2010)
- Wang TS, "Clinical experience of ustekinumab in the treatment of erythrodermic psoriasis: a case series", J Dermatol, 38, pp.1096~1099 (2011)
- Viguier M, "Efficacy and safety of biologics in erythrodermic psoriasis: a multicentre, retrospective study", Br J Dermatol, 167, pp.417~423 (2012)
- 이은주, "A Clinical Trial of Combination Therapy with Etanercept and Low Dose Cyclosporine for the Treatment of Refractory Psoriasis", Annals of Dermatology, 22(2), pp.138~142 (2010), 대한피부과학회
- Lizzul PF, "Differential expression of phosphorylated NF-kappaB", RelA in normal and psoriatic epidermis and downregulation of NF-kappaB in response to treatment with etanercept, 2005, pp.124, 1275~1283
- Kavanaugh A, "Treatment of psoriatic arthritis with tumor necrosis factor inhibitors: longer-term outcomes including enthesitis and dactylitis with golimumab treatment in the Longterm Extension of a Randomized, Placebocontrolled Study (GO-REVEAL)", J Rheumatol Suppl, 89, pp.90~93 (2012)
- Zhou H, "Pharmacokinetics and safety of golimumab, a fully human anti-TNF-alpha monoclonal antibody, in subjects with rheumatoid arthritis", J Clin Pharmacol, 47, pp.383~396 (2007)