만성 콩팥병 환자에서 저용량 바클로펜 사용 후 발생한 비경련뇌전증지속상태
Low Doses of Baclofen Induced Nonconvulsive Status Epilepticus in a Patient with Chronic Kidney Disease
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Baclofen, a gamma-aminobutyric acid B agonist, is frequently used in the treatment of various neurologic diseases including spasticity, dystonia and trigeminal neuralgia. This drug usually acts at the presynaptic motor neuron to induce an antispastic response. Oral baclofen toxicity is extremely rare, but is often reported to affect patients with renal disease. Here, we report a patient with chronic kidney disease who was treated with relatively low doses of baclofen (5 mg twice per day) and experienced nonconvulsive status epilepticus
Abstract
Baclofen, a gamma-aminobutyric acid B agonist, is frequently used in the treatment of various neurologic diseases including spasticity, dystonia and trigeminal neuralgia. This drug usually acts at the presynaptic motor neuron to induce an antispastic response. Oral baclofen toxicity is extremely rare, but is often reported to affect patients with renal disease. Here, we report a patient with chronic kidney disease who was treated with relatively low doses of baclofen (5 mg twice per day) and experienced nonconvulsive status epilepticus
참고문헌 (10)
- Zak R, "Baclofen-induced generalized nonconvulsive status epilepticus", Ann Neurol, 36, pp.113~114 (1994)
- Lipscomb DJ, "Baclofen overdose", Postgrad Med J, 56, pp.108~109 (1980)
- Kim JH, "A case of baclofen-induced encephalopathy", J Korean Neurol Assoc, 18, pp.337~340 (2000)
- Bowery N, "(–)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor", Nature, 283, pp.92~94 (1980)
- Saltuari L, "Status epilepticus complicating intrathecal baclofen overdose", Lancet, 339, pp.373~374 (1992)
- Cheng S, "Non-convulsive status epilepticus in the elderly", Epileptic Disord, 16, pp.385~394 (2014)
- Chatzikonstantinou A, "Cerebrospinal fluid findings after epileptic seizures", Epileptic Disord, 17, pp.453~459 (2015)
- Wu VC, "Treatment of baclofen overdose by haemodialysis: a pharmacokinetic study", Nephrol Dial Transplant, 20, pp.441~443 (2005)
- Porter LM, "Baclofen toxicity in a patient with hemodialysis-dependent end-stage renal disease", J Emerg Med, 52, pp.e99~e100 (2017)
- White WB, "Aggravated CNS depression with urinary retention secondary to baclofen administration", Arch Intern Med, 145, pp.1717~1718 (1985)