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심정지 이후 심한 젖산산증이 발생한 멜라스증후군 환자에서의 목표체온유지 치료

Targeted Temperature Management of Severe Lactic Acidosis in a Patient with MELAS Syndrome after Cardiac Arrest

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주제분류신경과학

초록

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is known as a maternally inherited mitochondrial disease with a m.3243A>G mutation in the MT-TL1 gene. Here, we report a case of targeted temperature management in a MELAS patient who had a cardiac arrest and severe lactic acidosis after recurrent seizures.

Abstract

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is known as a maternally inherited mitochondrial disease with a m.3243A>G mutation in the MT-TL1 gene. Here, we report a case of targeted temperature management in a MELAS patient who had a cardiac arrest and severe lactic acidosis after recurrent seizures.

참고문헌 (8)

  1. El-Hattab AW, "MELAS syndrome: clinical manifestations, pathogenesis, and treatment options", Mol Genet Metab, 116, pp.4~12 (2015)
  2. 김중구, "뇌전증지속상태를 초기증상으로 보인 멜라스증후군", 대한신경과학회지, 38(4), pp.276~280 (2020), 대한신경과학회
  3. Fryer RH, "Mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes (MELAS): a case report and critical reappraisal of treatment options", Pediatr Neurol, 56, pp.59~61 (2016)
  4. Yasuhiro Kuroda, "Targeted temperature management for postcardiac arrest syndrome", Journal of Neurocritical Care, 13(1), pp.1~18 (2020), 대한신경집중치료학회
  5. Sekhon MS, "Clinical pathophysiology of hypoxic ischemic brain injury after cardiac arrest: a "two-hit" model", Crit Care, 13(21), pp.90~ (2017)
  6. Bro-Jeppesen J, "Post-hypothermia fever is associated with increased mortality after out-of-hospital cardiac arrest", Resuscitation, 84, pp.1734~1770 (2013)
  7. Kim YJ, "Role of blood gas analysis during cardiopulmonary resuscitation in out-of-hospital cardiac arrest patients", Medicine, 95, pp.e3960~ (2016)
  8. Cope TE, "Rapid-onset, linezolid-induced lactic acidosis in MELAS", Mitochondrion, 11, pp.992~993 (2011)

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