A Study of the Changes of T Helper 17 Cells and Regulatory T Cells in Herpes Zoster
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Immunosuppression and age-related deficiencies in cell-mediated immunity are important factors for the reactivation of latent varicella-zoster virus (VZV). CD4+CD25+Foxp3+ regulatory T (Treg) cells and T helper 17 (Th17) cells are closely associated with various viral infections. Objective: We analyzed Treg cells and Th17 cells in patients with herpes zoster and investigated their relationship with the reactivation of latent VZV. Methods: Treg and Th17 cells in peripheral blood and the ratio of Th17 to Treg cells were examined in patients with herpes zoster and healthy controls. Changes between pre-treatment and post-treatment estimates of Treg and Th17 cells and clinical parameters in patients with herpes zoster were also analyzed. Results: The proportion of circulating Th17 cells and the Th17/Treg cell ratio were significantly higher in patients with herpes zoster than controls (p=0.012, 0.013), but there was no significant difference in the proportion of Treg cells between groups. There was no significant difference in the proportions of Treg and Th17 cells and the Th17/Treg cell ratio before and after treatment and between the non-postherpetic neuralgia and postherpetic neuralgia groups. Changes in Treg and Th17 cells and the Th17/Treg cell ratio were not significantly correlated with changes in the visual analog scale. Body surface area was significantly correlated with Treg cells, Th17 cells, and the Th17/Treg cell ratio (p=0.022, 0.002, 0.004). Conclusion: An imbalance between Th17 and Treg cells is associated with the reactivation of VZV, which may contribute to pathogenesis of herpes zoster.
Abstract
Background: Immunosuppression and age-related deficiencies in cell-mediated immunity are important factors for the reactivation of latent varicella-zoster virus (VZV). CD4+CD25+Foxp3+ regulatory T (Treg) cells and T helper 17 (Th17) cells are closely associated with various viral infections. Objective: We analyzed Treg cells and Th17 cells in patients with herpes zoster and investigated their relationship with the reactivation of latent VZV. Methods: Treg and Th17 cells in peripheral blood and the ratio of Th17 to Treg cells were examined in patients with herpes zoster and healthy controls. Changes between pre-treatment and post-treatment estimates of Treg and Th17 cells and clinical parameters in patients with herpes zoster were also analyzed. Results: The proportion of circulating Th17 cells and the Th17/Treg cell ratio were significantly higher in patients with herpes zoster than controls (p=0.012, 0.013), but there was no significant difference in the proportion of Treg cells between groups. There was no significant difference in the proportions of Treg and Th17 cells and the Th17/Treg cell ratio before and after treatment and between the non-postherpetic neuralgia and postherpetic neuralgia groups. Changes in Treg and Th17 cells and the Th17/Treg cell ratio were not significantly correlated with changes in the visual analog scale. Body surface area was significantly correlated with Treg cells, Th17 cells, and the Th17/Treg cell ratio (p=0.022, 0.002, 0.004). Conclusion: An imbalance between Th17 and Treg cells is associated with the reactivation of VZV, which may contribute to pathogenesis of herpes zoster.
참고문헌 (19)
- Schmader KE, "Fitzpatrick's dermatology in general medicine", pp.2386~ (2012), McGraw-Hill
- Vukmanovic-Stejic M, "The characterization of varicella zoster virus-specific T cells in skin and blood during aging", J Invest Dermatol, 135, pp.1752~1762 (2015)
- Xing Q, "Role of regulatory T cells in patients with acute herpes zoster and relationship to postherpetic neuralgia", Arch Dermatol Res, 305, pp.715~722 (2013)
- Steain M, "Analysis of T cell responses during active varicella-zoster virus reactivation in human ganglia", J Virol, 88, pp.2704~2716 (2014)
- Martinez NE, "Regulatory T cells and Th17 cells in viral infections: implications for multiple sclerosis and myocarditis", Future Virol, 7, pp.593~608 (2012)
- Xue-Song L, "Changes of Treg and Th17 cells balance in the development of acute and chronic hepatitis B virus infection", BMC Gastroenterol, 12, pp.43~ (2012)
- Hao C, "Imbalance of regulatory T cells and T helper type 17 cells in patients with chronic hepatitis C", Immunology, 143, pp.531~538 (2014)
- Falaki F, "The effect of low-level laser therapy on trigeminal neuralgia: a review of literature", J Dent Res Dent Clin Dent Prospects, 8, pp.1~5 (2014)
- Arvin A, "Human herpesviruses: biology, therapy, and immunoprophylaxis", pp.700~712 (2007), Cambridge University Press
- 노남경, "Awareness, Knowledge, and Vaccine Acceptability of Herpes Zoster in Korea: A Multicenter Survey of 607 Patients", Annals of Dermatology, 27(5), pp.531~538 (2015), 대한피부과학회
- Chen Y, "Effects of the Treg", Th17 cell balance and their associated cytokines in patients with hepatitis B infection, 2015, pp.9, 573~578
- Li S, "Natural regulatory T cells and persistent viral infection", J Virol, 82, pp.21~30 (2008)
- Rushbrook SM, "Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection", J Virol, 79, pp.7852~7859 (2005)
- Vukmanovic-Stejic M, "Varicella zoster-specific CD4+Foxp3+ T cells accumulate after cutaneous antigen challenge in humans", J Immunol, 190, pp.977~986 (2013)
- Hou W, "Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection", J Exp Med, 206, pp.313~328 (2009)
- Zajkowska A, "Evaluation of chosen cytokine levels among patients with herpes zoster as ability to provide immune response", PLoS One, 11, pp.e0150301~ (2016)
- Weinberg A, "Immune correlates of herpes zoster in HIV-infected children and youth", J Virol, 86, pp.2878~2881 (2012)
- Xu L, "Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGFbeta", J Immunol, 178, pp.6725~6729 (2007)
- DuPage M, "Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease", Nat Rev Immunol, 16, pp.149~163 (2016)