Aggressive Indeterminate Dendritic Cell Tumor Mimicking Scalp Angiosarcoma
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Indeterminate dendritic cell tumor (IDCT) is a proliferation of CD1a+, S100+ and langerin- histiocytes with a generally benign course. Here, we describe a case of a 90-year-old male who developed skin lesions on his scalp mimicking angiosarcoma and lymphadenopathy. He died six months after the onset of skin lesions despite of months’ radiotherapy. Pathological examination ruled out scalp angiosarcoma and showed a high Ki-67 index. The appearance of skin lesions and lymphadenopathy led to challenges in diagnosis and the development of a treatment plan.
Abstract
Indeterminate dendritic cell tumor (IDCT) is a proliferation of CD1a+, S100+ and langerin- histiocytes with a generally benign course. Here, we describe a case of a 90-year-old male who developed skin lesions on his scalp mimicking angiosarcoma and lymphadenopathy. He died six months after the onset of skin lesions despite of months’ radiotherapy. Pathological examination ruled out scalp angiosarcoma and showed a high Ki-67 index. The appearance of skin lesions and lymphadenopathy led to challenges in diagnosis and the development of a treatment plan.
참고문헌 (13)
- Rezk SA, "Indeterminate cell tumor: a rare dendritic neoplasm", Am J Surg Pathol, 32, pp.1868~1876 (2008)
- Valladeau J, "Langerin", CD207 sheds light on formation of birbeck granules and their possible function in Langerhans cells, 2003, pp.28, 93~107
- Brown RA, "ETV3-NCOA2 in indeterminate cell histiocytosis:clonal translocation supports sui generis", Blood, 126, pp.2344~2345 (2015)
- Deng A, "Primary cutaneous Langerhans cell sarcoma without Birbeck granules: indeterminate cell sarcoma?", J Cutan Pathol, 35, pp.849~854 (2008)
- Vener C, "Indeterminate cell histiocytosis in association with later occurrence of acute myeloblastic leukaemia", Br J Dermatol, 156, pp.1357~1361 (2007)
- Mo X, "Primary indeterminate dendritic cell tumor of skin correlated to mosquito bite", Medicine (Baltimore), 94, pp.e1443~ (2015)
- Chen M, "Indeterminate cell tumor of the spleen", Hum Pathol, 43, pp.307~311 (2012)
- McKenney JK, "CD31 expression in intratumoral macrophages: a potential diagnostic pitfall", Am J Surg Pathol, 25, pp.1167~1173 (2001)
- Vanchinathan V, "The vascular marker CD31 also highlights histiocytes and histiocyte-like cells within cutaneous tumors", Am J Clin Pathol, 143, pp.177~185 (2015)
- Malhomme de la Roche H, "Indeterminate cell histiocytosis responding to total skin electron beam therapy", Br J Dermatol, 158, pp.838~840 (2008)
- Ishibashi M, "Indeterminate cell histiocytosis successfully treated with ultraviolet B phototherapy", Clin Exp Dermatol, 33, pp.301~304 (2008)
- Yin R, "Recurrent generalized indeterminate cell histiocytosis: a case report", J Am Acad Dermatol, 63, pp.e3~e5 (2010)
- Fournier J, "Successful treatment of indeterminate cell histiocytosis with low-dose methotrexate", J Dermatol, 38, pp.937~939 (2011)