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고지혈증을 가진 뇌경색 환자에서 Statin에 의한 혈소판의 CD63과 CD40L의 발현의 억제

Statin Reduced the Platelet CD63 and CD40L Expression in Atherosclerotic Ischemic Stroke with Hyperlipidemia

조월순|정민호|임영진|차재관|이경미|박귀선
대한신경과학회 (Korean Neurological Association)|2004.10|대한신경과학회지 (Journal of the Korean Neurological Association)|제22권 제5호|pp. 453-458

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참고문헌

주제분류신경과학

초록

Abstract

Background: Statin (HMG-coA-reductase inhibitor) has been known to protect vessels from atherothrombosis through various mechanisms. In this study, we evaluated the effects of statin on reducing the platelet expressions of CD63 and CD40 ligand (CD40L) in subjects with atherosclerotic ischemic stroke. Methods: Twenty-one patients (17 men, 4 women; mean age 59.0±10.2 years) with atherosclerotic ischemic stroke were recruited. They took simvastatin 20 mg per day for 90 days and discontinued for another 90 days. We studied the changes of platelet expressions of CD63 and CD40L in all the patients after the use and discontinuance of simvastatin using whole blood flow cytometry. Results: After taking simvastatin 20mg for 90 days, the serum concentrations of LDL cholesterol decreased significantly (96.4±31.4 mg/dL, p<0.001) compared with those at the baseline (158.8±25.0 mg/dL). The platelet CD63 and C40L expressions were also significantly reduced by treatment of simvastatin 20 mg for 12 weeks (p<0.05). However, the effects of statin on CD63 and CD40L expressions disappeared after 12 weeks of cessation. Furthermore, changes of expressions of CD63 and CD40L by statin did not correlate with its cholesterol lowering effect (r=-0.311, p=0.386). Conclusions: This study demonstrates that the use of statin may be a helpful strategy to regulate the platelet activation in patients with atherosclerotic ischemic stroke.

참고문헌 (27)

  1. "Mechanisms of disease:atherosclerosis is an inflammatory disease", 340, pp.115~126 (1999)
  2. "Platelet activation mechanisms and markers in arterial thrombosis", 239, pp.17~34 (1996)
  3. "A receptor for neutrophils and Monocytes on activated platelets and endothelium", 45, pp.156~161 (1991)
  4. "The inflammatory action of CD40 ligand(CD154)expressed on activated human platelets is temporally limited by coexpressed CD40", 98, pp.1047~1054 (2001)
  5. "Platelet-derived CD40L:the switch-hitting player of cardiovascular disease", 106, pp.896~899 (2002)
  6. "Upregulation of CD40-CD40 ligand(CD154)in patients with acute cerebral ischemia", 34, pp.1412~1428 (2003)
  7. "Hypercholesterolemia,lipid-lowering agents,and the risk for brain infarction", 57, pp.~44 (2001)
  8. "Stroke prevention therapy beyond antithrombotics unifying mechanisms in ischemic stroke pathogenesis and implications for therapy", pp.862~875
  9. "Effects of statins in reducing thrombotic risk and modulating plaque vulnerability", 26, pp.~14 (2003)
  10. "anti-inflammatory effects beyond lipid lowering", pp.169~179 (2003)
  11. "Ensuring reliability of outcome measures in multicenter clinical trials of treatments for acute ischemic stroke The program developed for the Trial of Org 10172 in Acute Stroke Treatment", pp.1746~1751
  12. "Circulating platelets shows increased activation in patients with acute cerebral ischemia", 81, pp.373~377 (1999)
  13. "Course of platelet activation markers after ischemic stroke", 33, pp.2570~2574 (2002)
  14. "Serial measurements of CD63,P-selectin and CD40 ligand on platelets in Atherosclerotic ischemic stroke", 16, pp.376~382 (2003)
  15. "Soluble CD40L and cardiovascular risk in women", 104, pp.2266~2268 (2001)
  16. "Atherosclerosis:the emerging role of inflammation and the CD40-CD40 ligand system", 97, pp.6930~6932 (2000)
  17. "Reduction of platelet activity markers in type II hypercholesterolemic patients by a HMG-CoA-reductase inhibitor", 95, pp.229~234 (1999)
  18. "Reduced platelet aggregation after fluvastatin therapy is associated with altered platelet lipid composition and drug binding to the platelets", 44, pp.77~83 (1997)
  19. "Association between enhanced soluble CD40L and prothrombotic state in hypercholesterolemia:effects of statin therapy", 106, pp.399~402 (2002)
  20. "Statin enhances cytokine- mediated induction of nitric oxide synthesis in vascular smooth muscle cells", 54, pp.649~658 (2002)
  21. "Relation of inflammation and benefit of statins after percutaneous coronary interventions", 107, pp.1750~1756 (2003)
  22. "Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets", 95, pp.2387~2394 (1997)
  23. "Risk factors for early recurrence after ischemic stroke:the role of stroke syndrome and subtype", 29, pp.2118~2124 (1998)
  24. "The Serial Change of Platelet Activation for 90 days in Patients with Atherosclerotic Ischemic Stroke", 21, pp.334~338 (2003)
  25. "Routine statin treatment after acute coronary syndromes", pp.940~942 (2002)
  26. "Increased thrombotic vascular events after change of statin", 352, pp.1830~1831 (1998)
  27. "Risks and benefits of continued aggressive statin therapy", 26, pp.~12 (2003)

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