Psoriasis, Vitiligo and Crohn’s Disease Co-Existing in a Single Patient: A Variant Type of Multiple Autoimmune Syndrome?
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Multiple autoimmune syndrome (MAS) is a rare condition, in which at least three well-defined autoimmune diseases co-occur in a single patient. Although the pathogenesis of MAS remains poorly understood, genetic, immunological, hormonal, and environmental factors may all play a role. Although three classic subtypes of MAS are well known, several cases that could not be placed into any of these three categories have recently been reported. To the best of our knowledge, the co-existence of psoriasis, vitiligo, and Crohn’s disease has been reported in only one patient, who had a total of five autoimmune diseases (alopecia areata and oral lichen planus in addition to the three conditions mentioned). We herein describe a rare case of MAS presenting with psoriasis, vitiligo, and Crohn’s disease, and suggest that tumor necrosis factor-α may be associated with the pathogenesis of all three conditions.
Abstract
Multiple autoimmune syndrome (MAS) is a rare condition, in which at least three well-defined autoimmune diseases co-occur in a single patient. Although the pathogenesis of MAS remains poorly understood, genetic, immunological, hormonal, and environmental factors may all play a role. Although three classic subtypes of MAS are well known, several cases that could not be placed into any of these three categories have recently been reported. To the best of our knowledge, the co-existence of psoriasis, vitiligo, and Crohn’s disease has been reported in only one patient, who had a total of five autoimmune diseases (alopecia areata and oral lichen planus in addition to the three conditions mentioned). We herein describe a rare case of MAS presenting with psoriasis, vitiligo, and Crohn’s disease, and suggest that tumor necrosis factor-α may be associated with the pathogenesis of all three conditions.
참고문헌 (19)
- Humbert P, "Dermatological autoimmune diseases and the multiple autoimmune syndromes", Acta Derm Venereol Suppl (Stockh), 148, pp.1~8 (1989)
- Masood S, "Multiple autoimmune syndromes associated with psoriasis:a rare clinical presentation", Oman Med J, 29, pp.130~131 (2014)
- Anaya JM, "The multiple autoimmune syndromes. A clue for the autoimmune tautology", Clin Rev Allergy Immunol, 43, pp.256~264 (2012)
- Wilson JC, "Inflammatory bowel disease and the risk of autoimmune diseases", J Crohns Colitis, 10, pp.186~193 (2016)
- Cojocaru M, "Multiple autoimmune syndrome", Maedica (Buchar), 5, pp.132~134 (2010)
- Humbert P, "Multiple autoimmune syndromes", Ann Med Interne (Paris), 139, pp.159~168 (1988)
- Pasić A, "Coexistence of psoriasis vulgaris, bullous pemphigoid and vitiligo: a case report", J Eur Acad Dermatol Venereol, 16, pp.426~427 (2002)
- Topal F, "A new combination of multiple autoimmune syndrome? Coexistence of vitiligo, autoimmune thyroid disease and ulcerative colitis", Dermatol Reports, 3, pp.e19~ (2011)
- Barthel C, "Induction or exacerbation of psoriasis in patients with Crohn's disease under treatment with anti-TNF antibodies", Digestion, 89, pp.209~215 (2014)
- 이혜민, "Prevalence of Vitiligo and Associated Comorbidities in Korea", Yonsei Medical Journal, 56(3), pp.719~725 (2015), 연세대학교의과대학[DOI]
- Al-Mamari F, "HLA Antigens in Omani Psoriasis Vulgaris Patients", Oman Med J, 24, pp.27~29 (2009)
- Santos G, "Syndrome in question. Multiple autoimmune syndrome", An Bras Dermatol, 89, pp.361~362 (2014)
- Kim M, "Inflammatory bowel disease is associated with an increased risk of inflammatory skin diseases: a population-based cross-sectional study", J Am Acad Dermatol, 76, pp.40~48 (2017)
- Smith RL, "Polymorphisms in the IL-12beta and IL-23R genes are associated with psoriasis of early onset in a UK cohort", J Invest Dermatol, 128, pp.1325~1327 (2008)
- Kim SW, "Genetic polymorphisms of IL-23R and IL-17A and novel insights into their associations with inflammatory bowel disease", Gut, 60, pp.1527~1536 (2011)
- Ismail WA, "Vitiligo in a patient receiving infliximab for refractory ulcerative colitis", Arab J Gastroenterol, 12, pp.109~111 (2011)
- Posada C, "Vitiligo during treatment of Crohn's disease with adalimumab:adverse effect or co-occurrence?", Case Rep Dermatol, 3, pp.28~31 (2011)
- 박진모, "A Case of Concurrent Vitiligo and Psoriasis", Annals of Dermatology, 21(3), pp.330~333 (2009), 대한피부과학회
- Karn D, "Concurrent vitiligo and psoriasis", Kathmandu Univ Med J, 10, pp.83~84 (2012)