Treatment of Palmar Hyperhidrosis with Tap Water Iontophoresis: A Randomized, Sham-Controlled, Single-Blind, and Parallel-Designed Clinical Trial
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Background: Palmar hyperhidrosis is a common disorder of excessive sweating. A number of studies have demonstrated the effectiveness of iontophoresis in the treatment of palmar hyperhidrosis. However, controlled clinical studies on iontophoresis for palmar hyperhidrosis have been limited. Objective: To determine the efficacy and safety of iontophoresis in the treatment of palmar hyperhidrosis with a randomized, sham-controlled, single-blind, and parallel-designed study. Methods: Twenty nine patients with significant palmar hyperhidrosis were enrolled in this study. They received active iontophoresis treatment (group A) or sham treatment (group B). Iontophoresis was performed 20 minutes each time, five times per week, for 2 weeks. Its efficacy was assessed with starch-iodine test, mean sweat secretion rate, and hyperhidrosis disease severity scale. Results: Twenty-seven of the 29 patients completed the 2-week treatment. After completion of 10 times of treatment, results of the starch-iodine test showed clinical improvement in 92.9% of patients in group A and 38.5% of patients in group B (p=0.001). The mean sweat secretion rate was reduced by 91.8% of patients in group A and by 39.1% of patients in group B (p＜0.001). Improvement in quality of life was reported by 78.6% of patients in group A and by 30.8% of patients in group B (p=0.028). In group A, one case of localized adverse event was noted, although no adverse event was encountered in group B. Conclusion: Tap water iontophoresis could be used as an effective and safe treatment modality for palmar hyperhidrosis.
Abstract
Background: Palmar hyperhidrosis is a common disorder of excessive sweating. A number of studies have demonstrated the effectiveness of iontophoresis in the treatment of palmar hyperhidrosis. However, controlled clinical studies on iontophoresis for palmar hyperhidrosis have been limited. Objective: To determine the efficacy and safety of iontophoresis in the treatment of palmar hyperhidrosis with a randomized, sham-controlled, single-blind, and parallel-designed study. Methods: Twenty nine patients with significant palmar hyperhidrosis were enrolled in this study. They received active iontophoresis treatment (group A) or sham treatment (group B). Iontophoresis was performed 20 minutes each time, five times per week, for 2 weeks. Its efficacy was assessed with starch-iodine test, mean sweat secretion rate, and hyperhidrosis disease severity scale. Results: Twenty-seven of the 29 patients completed the 2-week treatment. After completion of 10 times of treatment, results of the starch-iodine test showed clinical improvement in 92.9% of patients in group A and 38.5% of patients in group B (p=0.001). The mean sweat secretion rate was reduced by 91.8% of patients in group A and by 39.1% of patients in group B (p＜0.001). Improvement in quality of life was reported by 78.6% of patients in group A and by 30.8% of patients in group B (p=0.028). In group A, one case of localized adverse event was noted, although no adverse event was encountered in group B. Conclusion: Tap water iontophoresis could be used as an effective and safe treatment modality for palmar hyperhidrosis.
참고문헌 (22)
- Callejas MA, "Hyperhydrosis update", Actas Dermosifiliogr, 101, pp.110~118 (2010)
- Schlereth T, "Hyperhidrosis--causes and treatment of enhanced sweating", Dtsch Arztebl Int, 106, pp.32~37 (2009)
- Vorkamp T, "Hyperhidrosis: evolving concepts and a comprehensive review", Surgeon, 8, pp.287~292 (2010)
- Solish N, "A comprehensive approach to the recognition, diagnosis, and severity-based treatment of focal hyperhidrosis: recommendations of the Canadian Hyperhidrosis Advisory Committee", Dermatol Surg, 33, pp.908~923 (2007)
- Kurta AO, "Emerging nonsurgical treatments for hyperhidrosis", Thorac Surg Clin, 26, pp.395~402 (2016)
- Kim WO, "Topical glycopyrrolate for patients with facial hyperhidrosis", Br J Dermatol, 158, pp.1094~1097 (2008)
- Walling HW, "Treatment options for hyperhidrosis", Am J Clin Dermatol, 12, pp.285~295 (2011)
- Fujimoto T, "Pathophysiology and treatment of hyperhidrosis", Curr Probl Dermatol, 51, pp.86~93 (2016)
- Stolman LP, "Treatment of excess sweating of the palms by iontophoresis", Arch Dermatol, 123, pp.893~896 (1987)
- Dahl JC, "Treatment of hyperhidrosis manuum by tap water iontophoresis", Acta Derm Venereol, 69, pp.346~348 (1989)
- Kim YD, "Treatment of palmoplantar hyperhidrosis with iontophoresis", Korean J Dermatol, 28, pp.758~764 (1990)
- Chan LY, "Treatment of palmar hyperhidrosis using tap water iontophoresis: local experience", Hong Kong Med J, 5, pp.191~194 (1999)
- Karakoç Y, "Safe control of palmoplantar hyperhidrosis with direct electrical current", Int J Dermatol, 41, pp.602~605 (2002)
- Dogruk Kacar S, "Treatment of primary hyperhidrosis with tap water iontophoresis in paediatric patients: a retrospective analysis", Cutan Ocul Toxicol, 33, pp.313~316 (2014)
- Papa CM, "Mechanisms of eccrine anidrosis. I. High level blockade", J Invest Dermatol, 47, pp.1~9 (1966)
- Sato K, "Generation and transit pathway of H+ is critical for inhibition of palmar sweating by iontophoresis in water", J Appl Physiol, 75, pp.2258~2264 (1993)
- Ohshima Y, "Changes in Na+, K+ concentrations in perspiration and perspiration volume with alternating current iontophoresis in palmoplantar hyperhidrosis patients", Arch Dermatol Res, 300, pp.595~600 (2008)
- Anliker MD, "Tap water iontophoresis", Curr Probl Dermatol, 30, pp.48~56 (2002)
- Reinauer S, "Pulsed direct current iontophoresis as a possible new treatment for hyperhidrosis", Hautarzt, 46, pp.543~547 (1995)
- Bouman HD, "The treatment of hyperhidrosis of hands and feet with constant current", Am J Phys Med, 31, pp.158~169 (1952)
- Hölzle E, "Recommendations for tap water iontophoresis", J Dtsch Dermatol Ges, 8, pp.379~383 (2010)
- Reinauer S, "Iontophoresis with alternating current and direct current offset (AC", DC iontophoresis): a new approach for the treatment of hyperhidrosis, 1993, pp.129, 166~169