Natural History of Chronic Urticaria in Korea
2
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Data on the natural history and prognostic variables of chronic urticaria (CU) are rare and information about spontaneous remission of CU is limited. Objective: This study evaluated the natural history of CU and identified predictors for remission. Methods: Total 329 Korean patients with CU, who had follow-ups more than 6 months after diagnosis during a 7-year period in the department of dermatology in three university hospitals were enrolled. Clinical data and laboratory findings obtained by medical records and telephone interviews were analyzed, retrospectively. Results: The proportion recovered in 1, 3, and 5 years after the onset of CU was 10.8%, 18.8%, and 32.9%, respectively. The mean duration of CU was 6.3 years. There were no significant differences in median recovery time depending on sex, age group, severity of CU, and type of CU. The presence of angioedema was significantly related to CU severity. There were no differences in prognosis with respect to the presence of dermographism or angioedema. Patients with atopic dermatitis (AD) had a significantly worse prognosis than patients without a history of AD; but not in patients with the history of allergic rhinitis or asthma. Patients with abnormal laboratory findings did not differ significantly in prognosis. Conclusion: CU remission rate significantly differ according to the presence of AD. This study provides information about the natural course of CU of Korean patients.
Abstract
Data on the natural history and prognostic variables of chronic urticaria (CU) are rare and information about spontaneous remission of CU is limited. Objective: This study evaluated the natural history of CU and identified predictors for remission. Methods: Total 329 Korean patients with CU, who had follow-ups more than 6 months after diagnosis during a 7-year period in the department of dermatology in three university hospitals were enrolled. Clinical data and laboratory findings obtained by medical records and telephone interviews were analyzed, retrospectively. Results: The proportion recovered in 1, 3, and 5 years after the onset of CU was 10.8%, 18.8%, and 32.9%, respectively. The mean duration of CU was 6.3 years. There were no significant differences in median recovery time depending on sex, age group, severity of CU, and type of CU. The presence of angioedema was significantly related to CU severity. There were no differences in prognosis with respect to the presence of dermographism or angioedema. Patients with atopic dermatitis (AD) had a significantly worse prognosis than patients without a history of AD; but not in patients with the history of allergic rhinitis or asthma. Patients with abnormal laboratory findings did not differ significantly in prognosis. Conclusion: CU remission rate significantly differ according to the presence of AD. This study provides information about the natural course of CU of Korean patients.
참고문헌 (32)
- Sahiner UM, "Chronic urticaria : etiology and natural course in children", Int Arch Allergy Immunol, 156, pp.224~230 (2011)
- van der Valk PG, "The natural history of chronic urticaria and angioedema in patients visiting a tertiary referral centre", Br J Dermatol, 146, pp.110~113 (2002)
- 강혜선, "소아 만성 두드러기의 임상 양상 및 경과", Clinical and Experimental Pediatrics, 52(2), pp.205~212 (2009), 대한소아청소년과학회
- 반가영, "Clinical features of elderly chronic urticaria", The Korean Journal of Internal Medicine, 29(6), pp.800~806 (2014), 대한내과학회[DOI]
- Toubi E, "Clinical and laboratory parameters in predicting chronic urticaria duration : a prospective study of 139 patients", Allergy, 59, pp.869~873 (2004)
- Najib U, "A retrospective review of clinical presentation, thyroid autoimmunity, laboratory characteristics, and therapies used in patients with chronic idiopathic urticaria", Ann Allergy Asthma Immunol, 103, pp.496~501 (2009)
- Najib U, "The spectrum of chronic urticaria", Allergy Asthma Proc, 30, pp.1~10 (2009)
- 이은아, "만성 두드러기 환자에서 항히스타민제 치료 전후의 삶의 질 변화 및 임상 경과에 대한 연구", 대한피부과학회지, 48(9), pp.758~765 (2010), 대한피부과학회
- Kozel MM, "Natural course of physical and chronic urticaria and angioedema in 220patients", J Am Acad Dermatol, 45, pp.387~391 (2001)
- 이서영, "갑상선 자가항체와 만성 특발성 두드러기의 예후", Allergy Asthma & Respiratory Disease, 1(2), pp.151~156 (2013), 대한 소아알레르기 호흡기학회
- Komarow HD, "Dissociation between history and challenge in patients with physical urticaria", J Allergy Clin Immunol Pract, 2, pp.786~790 (2014)
- Schoepke N, "Diagnosis of urticaria", Indian J Dermatol, 58, pp.211~218 (2013)
- Jorge Sánchez, "Causal Relationship Between Anti-TPO IgE and Chronic Urticaria by In Vitro and In Vivo Tests", Allergy, Asthma & Immunology Research, 11(1), pp.29~42 (2019), 대한천식알레르기학회
- Greaves M, "Chronic urticaria", J Allergy Clin Immunol, 105, pp.664~672 (2000)
- Frank MM. 8, "Hereditary angioedema", J Allergy Clin Immunol, 121, pp.S398~S401 (2008)
- Humphreys F, "The characteristics of urticaria in 390 patients", Br J Dermatol, 138, pp.635~638 (1998)
- Quaranta JH, "The natural history and response to therapy of chronic urticaria and angioedema", Ann Allergy, 62, pp.421~424 (1989)
- Juhlin L, "Recurrent urticaria : clinical investigation of 330patients", Br J Dermatol, 104, pp.369~381 (1981)
- Ye YM, "Increased epidermal filaggrin in chronic idiopathic urticaria is associated with severity of urticaria", Ann Allergy Asthma Immunol, 112, pp.533~538 (2014)
- Champion RH, "Urticaria and angio-oedema. A review of 554 patients", Br J Dermatol, 81, pp.588~597 (1969)
- Kulthanan K, "Chronic idiopathic urticaria : prevalence and clinical course", J Dermatol, 34, pp.294~301 (2007)
- Kim S, "Influence of initial treatment modality on long-term control of chronic idiopathic urticaria", PLoS One, 8, pp.e69345~ (2013)
- Park HH, "Natural course and prognostic factors of chronic urticaria in Korean children : a single center experience", Asian Pac J Allergy Immunol, 37, pp.19~24 (2019)
- Olze H, "Comorbidities between nose and skin allergy", Curr Opin Allergy Clin Immunol, 11, pp.457~463 (2011)
- Darlenski R, "Chronic urticaria as a systemic disease", Clin Dermatol, 32, pp.420~423 (2014)
- Ye YM, "Co-existence of chronic urticaria and metabolic syndrome : clinical implications", Acta Derm Venereol, 93, pp.156~160 (2013)
- Böhme M, "Atopic dermatitis and concomitant disease patterns in children up to two years of age", Acta Derm Venereol, 82, pp.98~103 (2002)
- Magen E, "Clinical and laboratory features of chronic idiopathic urticaria in the elderly", Int J Dermatol, 52, pp.1387~1391 (2013)
- Champion RH, "Urticaria : then and now", Br J Dermatol, 119, pp.427~436 (1988)
- Kozel MM, "Laboratory tests and identified diagnoses in patients with physical and chronic urticaria and angioedema : a systematic review", J Am Acad Dermatol, 48, pp.409~416 (2003)
- Godse KV, "Chronic urticaria and treatment options", Indian J Dermatol, 54, pp.310~312 (2009)
- Zuberbier T, "Pseudoallergen-free diet in the treatment of chronic urticaria. A prospective study", Acta Derm Venereol, 75, pp.484~487 (1995)