홍소발작-시상하부과오종증후군 환자 두 명의 발작간극파 전류원분석
Current Source Analysis of Interictal Spikes in Two Patients With Gelastic Epilepsy-Hypothalamic Hamartoma Syndrome
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Background: Interictal spikes in gelastic epilepsy-hypothalamic hamartoma syndrome are mainly in the fronto-temporal area. Current source analysis of the interictal spikes has not been done enough. We tried the current source analysis in 2 patients with gelastic epilepsy-hypothalamic hamartoma syndrome using both of the discrete and distributed models. Methods: Twenty 1 sec epochs including the negative peak of the spikes, were selected from one or two electroencephalographic recordings respectively in each patient. These 20 epochs were averaged into a single spike. The current dipole sources of the averaged spike were analyzed and located on a spherical head model. The current source density of the negative peak point of the averaged spike was located on the Talairach human brain map. Results: The current dipole sources were in the right subcallosal gyrus, or the right or left anterior cingulate gyri. The current source density was distributed in the bilateral medial frontal area including the anterior cingulate gyri. Conclusions: The interictal spikes of patients with gelastic epilepsy-hypothalamic hamartoma syndrome may be generated by the current sources located in the bilateral medial frontal area.
Abstract
Background: Interictal spikes in gelastic epilepsy-hypothalamic hamartoma syndrome are mainly in the fronto-temporal area. Current source analysis of the interictal spikes has not been done enough. We tried the current source analysis in 2 patients with gelastic epilepsy-hypothalamic hamartoma syndrome using both of the discrete and distributed models. Methods: Twenty 1 sec epochs including the negative peak of the spikes, were selected from one or two electroencephalographic recordings respectively in each patient. These 20 epochs were averaged into a single spike. The current dipole sources of the averaged spike were analyzed and located on a spherical head model. The current source density of the negative peak point of the averaged spike was located on the Talairach human brain map. Results: The current dipole sources were in the right subcallosal gyrus, or the right or left anterior cingulate gyri. The current source density was distributed in the bilateral medial frontal area including the anterior cingulate gyri. Conclusions: The interictal spikes of patients with gelastic epilepsy-hypothalamic hamartoma syndrome may be generated by the current sources located in the bilateral medial frontal area.
참고문헌 (11)
- Harvey AS, "Epilepsy in Hypothalamic Hamartoma: Clinical and EEG Features", Semin Pediatr Neurol, 14, pp.60~64 (2007)
- Leal AJ, "Interictal spike EEG source analysis in hypothalamic hamartoma epilepsy", Clin Neurophysiol, 113, pp.1961~1969 (2002)
- Kwon OY, "Source localization of triphasic waves: implications for the pathophysiological mechanism", Clin EEG Neurosci, 38, pp.161~167 (2007)
- Pascual-Marqui RD, "Low resolution electromagnetic tomography: a new method for localizing electrical activity in the brain", Int J Psychophysiol, 18, pp.49~65 (1994)
- Ebersole JS, "Noninvasive localization of epileptogenic foci by EEG source modeling", Epilepsia, 41, pp.24~33 (2000)
- Munari C, "Role of the hypothalamic hamartoma in the genesis of gelastic fits (a videostereo-EEG study)", Electroencephalogr Clin Neurophysiol, 95, pp.154~160 (1995)
- Kuzniecky R, "Intrinsic epileptogenesis of hypothalamic hamartomas in gelastic epilepsy", Ann Neurol, 42, pp.60~67 (1997)
- Iwasa H, "Different patterns of dipole source localization in gelastic seizure with or without a sense of mirth", Neurosci Res, 43, pp.23~29 (2002)
- Weissenberger AA, "Aggression and psychiatric comorbidity in children with hypothalamic hamartomas and their unaffected siblings", J Am Acad Child Adolesc Psychiatry, 40, pp.696~703 (2001)
- Krings T, "Accuracy of EEG dipole source localization using implanted sources in the human brain", Clin Neurophysiol, 110, pp.106~114 (1999)
- Michel CM, "Grave de Peralta R. EEG source imaging", Clin Neurophysiol, 115, pp.2195~2222 (2004)