A Rare Case of Cutaneous T-Cell Lymphoma Accompanied by Acute Monoblastic Leukemia and Diffuse Large B-Cell Lymphoma
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
A 70-year-old female was referred for brown-to-gray colored papules and nodules on her lower legs. She had been diagnosed with diffuse large B-cell lymphoma (DLBCL) in her stomach, and myelodysplastic syndrome (MDS) by bone marrow biopsy. Three years after complete remission of DLBCL, she experienced DLBCL recurrence in her small bowel and was hospitalized. MDS had been stationary, but during the treatment of DLBCL, her laboratory findings suggested signs of leukemia. Bone marrow biopsy was done, and acute monoblastic leukemia (AMoL) was diagnosed. After 1 cycle of chemotherapy for AMoL, skin lesions developed, and her skin biopsy showed cutaneous T-cell lymphoma (CTCL). Terminal deoxynucleotidyl transferase staining and CD123 staining were negative, and bone marrow re-biopsy conducted after the skin lesion developed still showed monoblastic proliferation. Whether the CTCL represented with an AMoL lineage switch could not be completely proved due to the absence of molecular or clonal marker evaluations, but the possibility of coexistence of three different malignancies was higher. During treatment, a neutropenic fever developed, and the patient died due to sepsis. We herein report a rare case of CTCL accompanied by AmoL and DLBCL.
Abstract
A 70-year-old female was referred for brown-to-gray colored papules and nodules on her lower legs. She had been diagnosed with diffuse large B-cell lymphoma (DLBCL) in her stomach, and myelodysplastic syndrome (MDS) by bone marrow biopsy. Three years after complete remission of DLBCL, she experienced DLBCL recurrence in her small bowel and was hospitalized. MDS had been stationary, but during the treatment of DLBCL, her laboratory findings suggested signs of leukemia. Bone marrow biopsy was done, and acute monoblastic leukemia (AMoL) was diagnosed. After 1 cycle of chemotherapy for AMoL, skin lesions developed, and her skin biopsy showed cutaneous T-cell lymphoma (CTCL). Terminal deoxynucleotidyl transferase staining and CD123 staining were negative, and bone marrow re-biopsy conducted after the skin lesion developed still showed monoblastic proliferation. Whether the CTCL represented with an AMoL lineage switch could not be completely proved due to the absence of molecular or clonal marker evaluations, but the possibility of coexistence of three different malignancies was higher. During treatment, a neutropenic fever developed, and the patient died due to sepsis. We herein report a rare case of CTCL accompanied by AmoL and DLBCL.
참고문헌 (5)
- Amber KT, "Second primary malignancies in CTCL patients from 1992 to 2011: a SEER-based, populationbased study evaluating time from CTCL diagnosis, age, sex, stage, and CD30+ subtype", Am J Clin Dermatol, 17, pp.71~77 (2016)
- 김영재, "The Incidence of Other Primary Cancers in Patients with Cutaneous Lymphoma", Annals of Dermatology, 30(3), pp.335~341 (2018), 대한피부과학회
- Miyatake J, "Synchronous occurrence of mycosis fungoides, diffuse large B cell lymphoma and acute myeloid leukemia", Intern Med, 57, pp.1445~1453 (2018)
- Higuchi Y, "Lineage switch with t(6;11)(q27;q23)from T-cell lymphoblastic lymphoma to acute monoblastic leukemia at relapse", Cancer Genet, 209, pp.267~271 (2016)
- Rossi JG, "Lineage switch in childhood acute leukemia : an unusual event with poor outcome", Am J Hematol, 87, pp.890~897 (2012)