A Case Report of Multiple Capillary Hemangioma in a Chronic Myeloid Leukemia Patient Taking Tyrosine Kinase Inhibitors
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
A capillary hemangioma is a vascular tumor with small capillary sized vascular channel. Multiple capillary hemangioma in relation with drugs have been rarely reported. Here in, we report a case of multiple capillary hemangioma in patient diagnosed with chronic myeloid leukemia who received tyrosine kinase inhibitors (TKIs). Histopathological findings have shown capillary proliferation in the upper dermis, which is consistent with capillary hemangioma. Since TKIs can paradoxically activate the MEK/ERK pathway which is required for angiogenesis, we presumed that the lesions as the cutaneous side effects of TKI
Abstract
A capillary hemangioma is a vascular tumor with small capillary sized vascular channel. Multiple capillary hemangioma in relation with drugs have been rarely reported. Here in, we report a case of multiple capillary hemangioma in patient diagnosed with chronic myeloid leukemia who received tyrosine kinase inhibitors (TKIs). Histopathological findings have shown capillary proliferation in the upper dermis, which is consistent with capillary hemangioma. Since TKIs can paradoxically activate the MEK/ERK pathway which is required for angiogenesis, we presumed that the lesions as the cutaneous side effects of TKI
참고문헌 (14)
- George A, "Update on the classification of hemangioma", J Oral Maxillofac Pathol, 18(Suppl 1), pp.S117~S120 (2014)
- Usui S, "Case of multiple disseminated cutaneous lobular capillary hemangioma that developed while taking oral contraceptive pills", J Dermatol, 46, pp.e202~e203 (2019)
- Ciarcia R, "Comparison of dasatinib, nilotinib, and imatinib in the treatment of chronic myeloid leukemia", J Cell Physiol, 231, pp.680~687 (2016)
- Lee WJ, "Clinical and histopathologic analysis of 46 cases of cutaneous adverse reactions to imatinib", Int J Dermatol, 55, pp.e268~e274 (2016)
- Tonini G, "Recurrent scrotal hemangiomas during treatment with sunitinib", J Clin Oncol, 28, pp.e737~e738 (2010)
- Dika E, "Periungual pyogenic granuloma following imatinib therapy in a patient with chronic myelogenous leukemia", J Drugs Dermatol, 12, pp.512~513 (2013)
- Yıldırım R, "Effects of Imatinib, Nilotinib, Dasatinib on VEGF and VEGFR-1 levels in patients with chronic myelogenous leukemia", Eur J Gen Med, 13, pp.111~115 (2016)
- Pandey N, "Effect of imatinib on bone marrow morphology and angiogenesis in chronic myeloid leukemia", Adv Hematol, 2019, pp.1835091~ (2019)
- Greuber EK, "Role of ABL family kinases in cancer : from leukaemia to solid tumours", Nat Rev Cancer, 13, pp.559~571 (2013)
- Packer LM, "Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia", Cancer Cell, 20, pp.715~727 (2011)
- Murphy DA, "Inhibition of tumor endothelial ERK activation, angiogenesis, and tumor growth by sorafenib (BAY43-9006)", Am J Pathol, 169, pp.1875~1885 (2006)
- Campione E, "Kaposi's sarcoma in a patient treated with imatinib mesylate for chronic myeloid leukemia", Clin Ther, 31, pp.2565~2569 (2009)
- Torres JE, "Disseminated pyogenic granuloma developing after an exfoliative dermatitis", J Am Acad Dermatol, 32(2 Pt 1), pp.280~282 (1995)
- Pembroke AC, "Eruptive angiomata in malignant disease", Clin Exp Dermatol, 3, pp.147~156 (1978)