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Gender-Specific Differences in Gut Microbiota Composition Associated with Microbial Metabolites for Patients with Acne Vulgaris

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초록

Background: The gut microbial dysbiosis and gender differences in the pathogenesis of acne vulgaris have long been postulated respectively. However, there was no data about a gender- related discrepancy in gut microbiota and microbial metabolism in acne. Objective: This study aimed at identifying the underlying gender-related difference in gut mi- crobiota and metabolism in acne vulgaris. Methods: Fecal samples were collected from 43 acne patients and 43 age and gender-matched controls. Gut microbiota was analyzed by sequencingthe V3-V4 regionof gene and microbial metabolites were quantitatively detected using gas chromatography time-of-flight mass spectrometry. Results: Compared with healthy controls, the men had a lower abundance of 18 microbes such as Butyricicoccus Clostridium sensu stricto Faecalibaculum Bacillus Lactococcus Blautia Clostridiales Lachnospiracea incertae sedis Ruminococcus at genus level. However, the female patients only showed increased Clostridium sensu stricto and declined Oscilli-bacter Odoribacterin. Additionally, the disordered metabolism of fatty acids was identi- fied in male patients, while the dysbiosis of amino acids metabolism in female ones.Conclusion: The disorder of gut microbiota and metabolism in acne vulgaris was gender- specific, which supported the potential role of gender difference in the pathogenesis of this disease.

Abstract

Background: The gut microbial dysbiosis and gender differences in the pathogenesis of acne vulgaris have long been postulated respectively. However, there was no data about a gender- related discrepancy in gut microbiota and microbial metabolism in acne. Objective: This study aimed at identifying the underlying gender-related difference in gut mi- crobiota and metabolism in acne vulgaris. Methods: Fecal samples were collected from 43 acne patients and 43 age and gender-matched controls. Gut microbiota was analyzed by sequencingthe V3-V4 regionof gene and microbial metabolites were quantitatively detected using gas chromatography time-of-flight mass spectrometry. Results: Compared with healthy controls, the men had a lower abundance of 18 microbes such as Butyricicoccus Clostridium sensu stricto Faecalibaculum Bacillus Lactococcus Blautia Clostridiales Lachnospiracea incertae sedis Ruminococcus at genus level. However, the female patients only showed increased Clostridium sensu stricto and declined Oscilli-bacter Odoribacterin. Additionally, the disordered metabolism of fatty acids was identi- fied in male patients, while the dysbiosis of amino acids metabolism in female ones.Conclusion: The disorder of gut microbiota and metabolism in acne vulgaris was gender- specific, which supported the potential role of gender difference in the pathogenesis of this disease.

참고문헌 (42)

  1. Bhate K, "Epidemiology of acne vulgaris", Br J Dermatol, 168, pp.474~485 (2013)
  2. Kubota Y, "Community-based epidemiological study of psychosocial effects of acne in Japanese adolescents", J Dermatol, 37, pp.617~622 (2010)
  3. Cook-Bolden FE, "Tazarotene 0.045% lotion for the once-daily treatment of moderate-to-severe acne vulgaris in adult males", J Drugs Dermatol, 19, pp.78~85 (2020)
  4. Sugawara T, "Gender- and age-related differences in facial sebaceous glands in Asian skin, as observed by non-invasive analysis using three-dimensional ultrasound microscopy", Skin Res Technol, 25, pp.347~354 (2019)
  5. Demirkan S, "CAG polymorphism in the androgen receptor gene in women may be associated with nodulocystic acne", Postepy Dermatol Alergol, 36, pp.173~176 (2019)
  6. Kim MH, "Integrated targeted serum metabolomic profile and its association with gender, age, disease severity, and pattern identification in acne", PLoS One, 15, pp.e0228074~ (2020)
  7. Lain E, "Tretinoin 0.05% lotion for the once-daily treatment of moderate-to-severe acne vulgaris: impact of gender and race on efficacy and safety", J Drugs Dermatol, 18, pp.1128~1138 (2019)
  8. Harper JC, "The efficacy and tolerability of a fixed combination clindamycin (1.2%) and benzoyl peroxide (3.75%) aqueous gel in patients with facial acne vulgaris: gender as a clinically relevant outcome variable", J Drugs Dermatol, 14, pp.381~384 (2015)
  9. Vojvodic A, "Gut microbiota and the alteration of immune balance in skin diseases: from Nutraceuticals to fecal transplantation", Open Access Maced J Med Sci, 7, pp.3034~3038 (2019)
  10. Lee YB, "Potential role of the microbiome in acne: a comprehensive review", J Clin Med, 8, pp.987~ (2019)
  11. Deng Y, "Patients with acne vulgaris have a distinct gut microbiota in comparison with healthy controls", Acta Derm Venereol, 98, pp.783~790 (2018)
  12. Yan HM, "Gut microbiota alterations in moderate to severe acne vulgaris patients", J Dermatol, 45, pp.1166~1171 (2018)
  13. Hayashi N, "Establishment of grading criteria for acne severity", J Dermatol, 35, pp.255~260 (2008)
  14. Zhao L, "High throughput and quantitative measurement of microbial metabolome by gas chromatography", mass spectrometry using automated alkyl chloroformate derivatization, 2017, pp.89, 5565~5577
  15. Ni Y, "ADAP-GC 2.0:deconvolution of coeluting metabolites from GC", TOF-MS data for metabolomics studies, 2012, pp.84, 6619~6629
  16. Forsythe P, "Moody microbes or fecal phrenology: what do we know about the microbiota-gut-brain axis?", BMC Med, 14, pp.58~ (2016)
  17. Zouboulis CC, "Acne as a chronic systemic disease", Clin Dermatol, 32, pp.389~396 (2014)
  18. Santos-Marcos JA, "Sex differences in the gut microbiota as potential determinants of gender predisposition to disease", Mol Nutr Food Res, 63, pp.e1800870~ (2019)
  19. Santos-Marcos JA, "Influence of gender and menopausal status on gut microbiota", Maturitas, 116, pp.43~53 (2018)
  20. Gao X, "Body mass index differences in the gut microbiota are gender specific", Front Microbiol, 9, pp.1250~ (2018)
  21. Fransen F, "The impact of gut microbiota on genderspecific differences in immunity", Front Immunol, 8, pp.754~ (2017)
  22. Mueller S, "Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study", Appl Environ Microbiol, 72, pp.1027~1033 (2006)
  23. Markle JG, "Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity", Science, 339, pp.1084~1088 (2013)
  24. Morales P, "Impact of dietary lipids on colonic function and microbiota: an experimental approach involving orlistat-induced fat malabsorption in human volunteers", Clin Transl Gastroenterol, 7, pp.e161~ (2016)
  25. Scher JU, "Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease", Arthritis Rheumatol, 67, pp.128~139 (2015)
  26. Consolandi C, "Behçet’s syndrome patients exhibit specific microbiome signature", Autoimmun Rev, 14, pp.269~276 (2015)
  27. Boesmans L, "Butyrate producers as potential next-generation probiotics : safety assessment of the administration of Butyricicoccus pullicaecorum to healthy volunteers", mSystems, 3, pp.e00094~ (2018)
  28. Li JW, "Age- and diet-specific ef-fects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats", Pestic Biochem Physiol, 159, pp.68~79 (2019)
  29. Salem I, "The gut microbiome as a major regulator of the gut-skin axis", Front Microbiol, 9, pp.1459~ (2018)
  30. Schwarz A, "The short-chain fatty acid sodium butyrate functions as a regulator of the skin immune system", J Invest Dermatol, 137, pp.855~864 (2017)
  31. Huang S, "The imbalance of gut microbiota and its correlation with plasma inflammatory cytokines in pemphigus vulgaris patients", Scand J Immunol, 90, pp.e12799~ (2019)
  32. Ilinskaya ON, "Secretome of intestinal Bacilli : a natural guard against pathologies", Front Microbiol, 8, pp.1666~ (2017)
  33. Wise C, "Production and antimicrobial activity of 3-hydroxypropionaldehyde from Bacillus subtilis strain CU12", J Chem Ecol, 38, pp.1521~1527 (2012)
  34. Jung MJ, "Chronic repression of mTOR complex 2 induces changes in the gut microbiota of diet-induced obese mice", Sci Rep, 6, pp.30887~ (2016)
  35. Yafei Duan, "Effects of dietary poly-β-hydroxybutyrate (PHB) on microbiota composition and the mTOR signaling pathway in the intestines of Litopenaeus vannamei", The Journal of Microbiology, 55(12), pp.946~954 (2017), 한국미생물학회[DOI]
  36. Ozdarska K, "Diet in pathogenesis of acne vulgaris", Pol Merkur Lekarski, 43, pp.186~189 (2017)
  37. Costantini L, "Impact of omega-3 fatty acids on the gut microbiota", Int J Mol Sci, 18, pp.2645~ (2017)
  38. Wu C, "Rhizoma Amorphophalli inhibits TNBC cell proliferation, migration, invasion and metastasis through the PI3K", Akt, J Ethnopharmacol, pp.2018, 211[DOI]
  39. Yang YC, "Female gender and acne disease are jointly and independently associated with the risk of major depression and suicide : a national populationbased study", Biomed Res Int, 2014, pp.504279~ (2014)
  40. Geng S, "Gut microbiota are associated with psychological stress-induced defections in intestinal and blood-brain barriers", Front Microbiol, 10, pp.3067~ (2020)
  41. Lach G, "Anxiety, depression, and the microbiome: a role for gut peptides", Neurotherapeutics, 15, pp.36~59 (2018)
  42. Chi L, "Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model", Phytomedicine, 67, pp.153157~ (2020)

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