Zonisamide 혹은 Topiramate를 사용한 뇌전증 환자에서 항뇌전증제 투약 전후 삶의 질 비교
Comparison of Quality of Life in Patients with Epilepsy Taking Zonisamide or Topiramate: Before and After Treatment
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Background: Patients with epilepsy experience impairments in their quality of life (QOL). The objective of this study was to determine the influences of clinical factors on QOL and to compare QOL before and after antiepileptic drug (AED) treatment. Methods: A cohort of 79 patients with epilepsy (43 male and 36 female) was recruited for this prospective study. The Quality of Life in Epilepsy (QOLIE)-31 survey was applied to evaluate QOL. The QOLIE-31 questionnaire was completed by the subjects before and 24 weeks after AED monotherapy (zonisamide or topiramate). The relationships of demographic, social, and clinical factors with QOL were evaluated. Results: There was a negative correlation between seizure frequency and QOL in patients with epilepsy (p<0.05). The scores of patients without adverse effect were significantly higher for the seizure worry item of the QOLIE-31 questionnaire at 24 weeks compared to baseline (p<0.05). No other significant differences were found for any of the other QOLIE-31 items. Conclusions: Age, sex, seizure frequency, AED treatment, and AED adverse effects were significant clinical factors affecting QOL in patients with epilepsy. It is suggested that the physician should recognize these factors and manage them appropriately to improve the QOL of patients with epilepsy.
Abstract
Background: Patients with epilepsy experience impairments in their quality of life (QOL). The objective of this study was to determine the influences of clinical factors on QOL and to compare QOL before and after antiepileptic drug (AED) treatment. Methods: A cohort of 79 patients with epilepsy (43 male and 36 female) was recruited for this prospective study. The Quality of Life in Epilepsy (QOLIE)-31 survey was applied to evaluate QOL. The QOLIE-31 questionnaire was completed by the subjects before and 24 weeks after AED monotherapy (zonisamide or topiramate). The relationships of demographic, social, and clinical factors with QOL were evaluated. Results: There was a negative correlation between seizure frequency and QOL in patients with epilepsy (p<0.05). The scores of patients without adverse effect were significantly higher for the seizure worry item of the QOLIE-31 questionnaire at 24 weeks compared to baseline (p<0.05). No other significant differences were found for any of the other QOLIE-31 items. Conclusions: Age, sex, seizure frequency, AED treatment, and AED adverse effects were significant clinical factors affecting QOL in patients with epilepsy. It is suggested that the physician should recognize these factors and manage them appropriately to improve the QOL of patients with epilepsy.
참고문헌 (29)
- Lowestein DH, "Harrison's principles of internal medicine. 16th ed", pp.2354~2369 (2001), New York: McGraw-Hill
- Lee CK, "Psychiatry", pp.520~540 (1981), Seoul: Il Cho Kak
- Lee BI, "Drug therapy in epilepsy", Seoul: Drug Information, 5, pp.41~44 (1990)
- Hartshorm JC, "Impact of epilepsy on quality of life", J Neurosci Nurs, 24, pp.24~29 (1992)
- Colling JA, "Epilepsy and well-being", Soc Sci Med, 31, pp.165~170 (1990)
- Padilla GV, "Quality of life as a cancer nursing outcome variable", ANS Adv Nur Sci, 8, pp.45~60 (1985)
- Kim MY, "The quality of life and its assessment in epilepsy", J Korean Epilep Soc, 1, pp.52~59 (1997)
- Kim JT, "The evaluation of quality of life in epileptic patient : the study of QOLIE-89", J Korean Epilep Soc, 5, pp.177~185 (2001)
- Youn SY, "Clinical factors influencing quality of life in patients with epilepsy", J Korean Neurol Assoc, 18, pp.156~161 (2000)
- Harden CL, "The effect of seizure severity on quality of life in epilepsy", Epilepsy Behav, 11, pp.208~211 (2007)
- Yoo HJ, "The reliability and validily of Korean QOLIE-31 in patients with epilepsy", J Korean Epilep Soc, 6, pp.45~52 (2002)
- Faught E, "Zonisamide 922 Trial Group. Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures", Neurology, 57, pp.1774~1779 (2001)
- Wilensky AJ, "Zonisamide in epilepsy: a pilot studuy", Epilepsia, 26, pp.212~220 (1985)
- Silberstein SD, "Topiramate monotherapy in epilepsy and migraine prevention", Clin Ther, 27, pp.154~165 (2005)
- Mukhin KIu, "Topamax in monotherapy of epilepsy", Zh Nevrol Psikhiatr Im S S Korsakova, 104, pp.35~40 (2004)
- Devinsky O, "Development of the quality of life in epilepsy inventory", Epilepsia, 36, pp.1089~1104 (1995)
- Jacoby A, "Determinants of quality of life in people with epilepsy", Neurol Clin, 27, pp.843~863 (2009)
- Auriel E, "Quality of life in seizure-free patients with epilepsy on monotherapy", Epilepsy Behav, 14, pp.130~133 (2009)
- Djibuti M, "Influence of clinical, demographic, and socioeconomic variables on quality of life in patients with epilepsy: findings from Georgian study", J Neurol Neurosurg Psychiatry, 74, pp.570~573 (2003)
- Djernes JK, "Prevalence and predictors of depression in populations of elderly: a review", Acta Psychiatr Scand, 113, pp.372~387 (2006)
- Kendler KS, "Gender differences in the rates of exposure to stressful life events and sensitivity to their depressogenic effects", Am J Psychiatry, 158, pp.587~593 (2001)
- Devinsky O, "Varieties of depression in epilepsy", Neuropsychiat, Neuropsychol and Behav Neurol, 49, pp.49~61 (1991)
- Baker GA, "The relationship between seizure frequency, seizure type and quality of life: findings from three european countries", Epilepsy Res, 30, pp.231~240 (1998)
- Thompson PJ, "Socioeconomic accompaniments of severe epilepsy", Epilepsia, 29, pp.9~18 (1988)
- O’Donoghue MF, "Assessing the psychosocial consequences of epilepsy: a communitybased study", Br J Gen Pract, 49, pp.211~214 (1999)
- Byeon JY, "Anxiety and depression in the epileptic patients", J Korean Neuropsychiatr Assoc, 27, pp.1035~1041 (1988)
- Guekht AB, "Factors influencing on quality of life in people with epilepsy", Seizure, 16, pp.128~133 (2007)
- Hermann BP, "Behavioral personality correlates of epilepsy, A review, Methodological Critique and Conceptual Model", Psychol Bull, 95, pp.451~497 (1984)
- Altshuler L, "Depression and epilepsy. In Epilepsy and Behaviour", pp.47~65 (1991), NewYork: A John Willey & Sons