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A Case of Malignant Transformation of Solitary Recurrent Cylindroma on Scalp

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초록

A 78-year-old male presented with an asymptomatic pinkish multi-nodular mass on hisfrontal scalp. The lesion had recurred twice after incomplete surgical excision. Initial punchbiopsy was diagnosed with cylindroma. He revisited after one year with exophytic enlarge-ment of the mass, and two staged Mohs micrographic surgery identified well-differentiatedmalignant cylindroma. Histopathology in the lower dermis and periosteal layer showedatypical cells with mitosis and hyperchromatic nucleoli with increased Ki-67 index of 10%to 30%. The postoperative wound was successfully treated with negative wound pressuretherapy (NPWT) and secondary intentional healing. We report this case showing malignanttransformation of solitary cylindroma, and good result for secondary intention healing us-ing NPWT for postoperative defect

Abstract

A 78-year-old male presented with an asymptomatic pinkish multi-nodular mass on hisfrontal scalp. The lesion had recurred twice after incomplete surgical excision. Initial punchbiopsy was diagnosed with cylindroma. He revisited after one year with exophytic enlarge-ment of the mass, and two staged Mohs micrographic surgery identified well-differentiatedmalignant cylindroma. Histopathology in the lower dermis and periosteal layer showedatypical cells with mitosis and hyperchromatic nucleoli with increased Ki-67 index of 10%to 30%. The postoperative wound was successfully treated with negative wound pressuretherapy (NPWT) and secondary intentional healing. We report this case showing malignanttransformation of solitary cylindroma, and good result for secondary intention healing us-ing NPWT for postoperative defect

참고문헌 (10)

  1. Foreman RK, "Fitzpatrick's dermatology", pp.1820~1853 (2019), McGraw-Hill
  2. Kuklani RM, "Malignant cylindroma of the scalp arising in a setting of multiple cylindromatosis : a case report", Head Neck Pathol, 3, pp.315~319 (2009)
  3. Durani BK, "Malignant transformation of multiple dermal cylindromas", Br J Dermatol, 145, pp.653~656 (2001)
  4. Bansal C, "Solitary cylindroma with malignant transformation", Indian J Dermatol, 57, pp.141~143 (2012)
  5. Donner LR, "Well-differentiated malignant cylindroma with partially preserved hyaline sheaths. A locally invasive neoplasm?", Am J Dermatopathol, 17, pp.169~173 (1995)
  6. Kim SM, "Malignant cylindroma of the scalp treated with staged perimeter excision : a case report and literature review", JPRAS Open, 30, pp.176~177 (2021)
  7. Cai SS, "Use of negative pressure wound therapy on malignant wounds-a case report and review of literature", Int Wound J, 14, pp.661~665 (2017)
  8. Riot S, "Is the use of negative pressure wound therapy for a malignant wound legitimate in a palliative context?"The concept of NPWT ad vitam" : a case series", Palliat Med, 29, pp.470~473 (2015)
  9. Pereira S, "Vacuum-assisted closure therapy after resection of giant basal cell carcinoma of the scalp", J Surg Case Rep, 2017, pp.rjx122~ (2017)
  10. Cunningham T, "Vacuum-assisted closure device and skin substitutes for complex Mohs defects", Dermatol Surg, 40(9), pp.120~126 (2014)

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