A Generalized Lichen Planus Following COVID-19 Vaccination: A Case Report
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As part of the efforts to overcome the ongoing coronavirus disease 2019 (COVID-19) pan- demic, mass vaccination programs against the severe acute respiratory syndrome coronavi- rus 2 (SARS-CoV-2) have been initiated. Since then, an increasing number of cutaneous ad- verse events associated with the COVID-19 vaccines have been reported. Lichen planus (LP) is a rare inf lammatory mucocutaneous disease with various clinical presentations, although uncommon, occurring following vaccination. There have been several cases of LP reported following COVID-19 vaccination. However, there has been no report of generalized LP fol- lowing the COVID-19 vaccine to our knowledge. Herein, we report a case of generalized LP following the Oxford/AstraZeneca (AZD1222) vaccine. A 68-year-old female presented with widespread, erythematous pruritic papules and plaques on the trunk and both limbs, which developed 2 to 3 days after administration of the AZD1222 vaccine. Histopathological ex- aminations revealed cellular interface dermatitis. The patient was diagnosed with general- ized LP and was successfully treated with systemic corticosteroid and cyclosporine. As the vaccination campaign against COVID-19 is ongoing and early recognition and treatment are essential to reduce the morbidity of this condition, clinicians should be aware that LP could follow COVID-19 vaccination regardless of the type of vaccine administered.
Abstract
As part of the efforts to overcome the ongoing coronavirus disease 2019 (COVID-19) pan- demic, mass vaccination programs against the severe acute respiratory syndrome coronavi- rus 2 (SARS-CoV-2) have been initiated. Since then, an increasing number of cutaneous ad- verse events associated with the COVID-19 vaccines have been reported. Lichen planus (LP) is a rare inf lammatory mucocutaneous disease with various clinical presentations, although uncommon, occurring following vaccination. There have been several cases of LP reported following COVID-19 vaccination. However, there has been no report of generalized LP fol- lowing the COVID-19 vaccine to our knowledge. Herein, we report a case of generalized LP following the Oxford/AstraZeneca (AZD1222) vaccine. A 68-year-old female presented with widespread, erythematous pruritic papules and plaques on the trunk and both limbs, which developed 2 to 3 days after administration of the AZD1222 vaccine. Histopathological ex- aminations revealed cellular interface dermatitis. The patient was diagnosed with general- ized LP and was successfully treated with systemic corticosteroid and cyclosporine. As the vaccination campaign against COVID-19 is ongoing and early recognition and treatment are essential to reduce the morbidity of this condition, clinicians should be aware that LP could follow COVID-19 vaccination regardless of the type of vaccine administered.
참고문헌 (18)
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