정상적인 한국인에서 아스트로마이신 1회 점적 주사후 약물동테학적 평가

Abstract

Astromicin is an aminoglycoside antibiotic that is structually different from conventional aminoglycosides. Astromicin has been shown to be active against aerobic Gram-negative bacilli. The pharmacokinetics of astromicin were determined in 12 healthy volunteers (65.5 ± 5.23 kg of body weight) following a 30-min continuous intravenous infusion at a dose of 200 mg. The plasma and urine samples were collected up to 24 h and drug concentrations were measured by a bioassay using Bacillus subtilis. Pharmacokinetic parameters were calculated by fitting individual concentration-time curve to a one-exponential decay model. The plasma levels were 16.9 ± 1.68 and 1.05 ± 0.346 g/ml at 0 h and 8 h after the infusion, respectively. The elimination half-life of astromicin was 1.86 ± 0.360 h. The volume of distribution was 0.182 ± 0.0164 L/kg, and the total body clearance was 5.25 ± 1.74 L/h. These pharmacokinetic parameters were similar to those of gentamicin, tobramycin, and amikacin. Therefore, it is recommended that therapeutic drug monitoring of astromicin could be conducted in a similar fashion as the other aminoglycosides.