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A Case of Mucosal Fixed Drug Eruption Caused by Tamsulosin Administration

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초록

Fixed drug eruption (FDE) is a rare type of drug reaction that involves the skin and, less commonly, the mucosal membranes. It is characterized by clinically well-defined erythema- tous patches or plaques with or without blisters, which relapse at the same location if the causative agent is readministered. Tamsulosin is an alpha-1 adrenergic receptor blocker used to treat benign prostatic hyperplasia, and its common side effects are dizziness and head- ache. Only one case of cutaneous FDE due to tamsulosin administration has been reported but no other case of mucosal involvement has been reported to date. Therefore, we present a case of mucosal FDE caused by tamsulosin administration along with a literature review.

Abstract

Fixed drug eruption (FDE) is a rare type of drug reaction that involves the skin and, less commonly, the mucosal membranes. It is characterized by clinically well-defined erythema- tous patches or plaques with or without blisters, which relapse at the same location if the causative agent is readministered. Tamsulosin is an alpha-1 adrenergic receptor blocker used to treat benign prostatic hyperplasia, and its common side effects are dizziness and head- ache. Only one case of cutaneous FDE due to tamsulosin administration has been reported but no other case of mucosal involvement has been reported to date. Therefore, we present a case of mucosal FDE caused by tamsulosin administration along with a literature review.

참고문헌 (5)

  1. Özkaya E, "Oral mucosal fixed drug eruption: characteristics and differential diagnosis", J Am Acad Dermatol, 69, pp.51~58 (2013)
  2. Montazer F, "A first case of fixed drug eruption due to Tamsulosin", J Cosmet Dermatol, 19, pp.1143~1145 (2020)
  3. 정재우, "Clinical Features of Fixed Drug Eruption at a Tertiary Hospital in Korea", Allergy, Asthma & Immunology Research, 6(5), pp.415~420 (2014), 대한천식알레르기학회
  4. Tan CK, "Tamsulosin-induced photosensitivity rash", Singapore Med J, 59, pp.336~337 (2018)
  5. Wulf NR, "Sulfonamide cross-reactivity : is there evidence to support broad cross-allergenicity?", Am J Health Syst Pharm, 70, pp.1483~1494 (2013)

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