대표적인 국제 소아 천식 약물요법 가이드라인에 대한 비교 연구
A Comparison of International Guidelines for Pediatric Asthma Pharmacotherapy
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Objective: International institutes such as Global institute for Asthma(GINA), KAAACI(Republic of Korea), NHLBI(USA), BTS(UK) andJSA(Japan) have published guidelines for asthma treatment. The aim of this study was to compare the representatives’ internationalguidelines of pharmacotherapy for pediatric asthma. Methods: The recommendations related to pharmacotherapy for pediatricasthma were extracted from the latest representatives’ international guidelines, and comprehensive comparisons were conducted. Results: Major comparison outcomes between international guidelines were evaluated as follows: classification system on severityand pediatric age group, recommendation for inhaled corticosteroid dose, recommendation for pediatric age group of theophyllinein mild asthma, and recommendation for pediatric age group of tiotropium in severe asthma. Clinical trials emphasized the adverseeffects of theophylline, whereas tiotropium demonstrated beneficial actions for pediatric asthma. Therefore, theophylline wasrecommended for older patients with persistent asthma, and tiotropium was considered to be suitable for younger patients with severeasthma according to GINA guidelines. Conclusion: These findings address the requirement to harmonize international guidelines ofpharmacotherapy in pediatric asthma. In addition, the findings suggest that KAAACI needs to update its pharmacotherapy guidelines oftheophylline, tiotropium and other medicines recently approved.
Abstract
Objective: International institutes such as Global institute for Asthma(GINA), KAAACI(Republic of Korea), NHLBI(USA), BTS(UK) andJSA(Japan) have published guidelines for asthma treatment. The aim of this study was to compare the representatives’ internationalguidelines of pharmacotherapy for pediatric asthma. Methods: The recommendations related to pharmacotherapy for pediatricasthma were extracted from the latest representatives’ international guidelines, and comprehensive comparisons were conducted. Results: Major comparison outcomes between international guidelines were evaluated as follows: classification system on severityand pediatric age group, recommendation for inhaled corticosteroid dose, recommendation for pediatric age group of theophyllinein mild asthma, and recommendation for pediatric age group of tiotropium in severe asthma. Clinical trials emphasized the adverseeffects of theophylline, whereas tiotropium demonstrated beneficial actions for pediatric asthma. Therefore, theophylline wasrecommended for older patients with persistent asthma, and tiotropium was considered to be suitable for younger patients with severeasthma according to GINA guidelines. Conclusion: These findings address the requirement to harmonize international guidelines ofpharmacotherapy in pediatric asthma. In addition, the findings suggest that KAAACI needs to update its pharmacotherapy guidelines oftheophylline, tiotropium and other medicines recently approved.
참고문헌 (18)
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