A Case of Rheumatoid Arthritis accompanied by Organizing Pneumonia Successfully Treated with Prednisolone, Clarithromycin and Tacrolimus
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A 74-year-old man suffering from cryptogenic organizing pneumonia (OP) visited our department with arthralgia accompanied withpartial swellings of proximal interphalangeal and metacarpophalangeal joints with morning stiffness. A diagnose of rheumatoidarthritis (RA) was made. It was thought that OP was associated with RA. We initiated a treatment with salazosulfapyridine andloxoprofen for RA. Although this treatment was effective, it was discontinued due to the development of drug eruption. As analternative, the patient was treated with prednisolone (PSL) and clarithromycin (CAM). This treatment demonstrated being effectivefor OP and RA, to a certain extent; however, the RA activity was not completely suppressed. In order to suppress the RA activityfurther, tacrolimus (TAC) was successfully added with increasing the dosage of CAM that is assumed to raise blood TACconcentrations. The present case shows that treatment with PSL, CAM and TAC may be effective in some cases of RA.
Abstract
A 74-year-old man suffering from cryptogenic organizing pneumonia (OP) visited our department with arthralgia accompanied withpartial swellings of proximal interphalangeal and metacarpophalangeal joints with morning stiffness. A diagnose of rheumatoidarthritis (RA) was made. It was thought that OP was associated with RA. We initiated a treatment with salazosulfapyridine andloxoprofen for RA. Although this treatment was effective, it was discontinued due to the development of drug eruption. As analternative, the patient was treated with prednisolone (PSL) and clarithromycin (CAM). This treatment demonstrated being effectivefor OP and RA, to a certain extent; however, the RA activity was not completely suppressed. In order to suppress the RA activityfurther, tacrolimus (TAC) was successfully added with increasing the dosage of CAM that is assumed to raise blood TACconcentrations. The present case shows that treatment with PSL, CAM and TAC may be effective in some cases of RA.
참고문헌 (13)
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