A Case of Palisaded Neutrophilic and Granulomatous Dermatitis Associated with an Initial Presentation in Ankylosing Spondylitis
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Palisaded neutrophilic and granulomatous dermatitis (PNGD) is an inf lammatory der- matosis associated with systemic immune-mediated diseases such as rheumatoid arthritis, systemic sclerosis, lupus erythematosus, and ulcerative colitis. Histologically, serial develop- ment of leukocytoclastic vasculitis is shown from an early stage, which can progress to pali- sading granuloma in the fully developed stage and to fibrosis in the final stage. A 32-year- old man presented with ankylosing spondylitis showing multiple erythematous papules on his fingers, elbows, knees, and left auricle. Histologic examination from his skin lesion revealed a perforating palisading granuloma with leukocytoclastic vasculitis, which was consistent with PNGD. Therefore, this study reported a case of PNGD accompanied by an- kylosing spondylitis as an initial presentation.
Abstract
Palisaded neutrophilic and granulomatous dermatitis (PNGD) is an inf lammatory der- matosis associated with systemic immune-mediated diseases such as rheumatoid arthritis, systemic sclerosis, lupus erythematosus, and ulcerative colitis. Histologically, serial develop- ment of leukocytoclastic vasculitis is shown from an early stage, which can progress to pali- sading granuloma in the fully developed stage and to fibrosis in the final stage. A 32-year- old man presented with ankylosing spondylitis showing multiple erythematous papules on his fingers, elbows, knees, and left auricle. Histologic examination from his skin lesion revealed a perforating palisading granuloma with leukocytoclastic vasculitis, which was consistent with PNGD. Therefore, this study reported a case of PNGD accompanied by an- kylosing spondylitis as an initial presentation.
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