Insulin-Derived Cutaneous Amyloidosis: A Possible Complication of Repeated Insulin Injections
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Primary localized cutaneous amyloidosis (PLCA) is characterized by extracellular deposi- tion of pathological fibril aggregation of proteins in the skin without systemic involvement. Macular amyloidosis, lichen (papular) amyloidosis, and nodular amyloidosis are three dif- ferent subtypes of PLCA. Although the pathological mechanism of PLCA has not yet been clarified, it is assumed that a nucleus formation of amyloid fibril is formed due to repeated external stimulation, such as subcutaneous injection, which often poses diagnostic chal- lenges. Herein, we present a 54-year-old Korean male patient with cutaneous localized amy- loidosis which occurred after repeated local insulin injections, and discuss the relationship between insulin therapy in patients with diabetes mellitus and dermal amyloid deposition.
Abstract
Primary localized cutaneous amyloidosis (PLCA) is characterized by extracellular deposi- tion of pathological fibril aggregation of proteins in the skin without systemic involvement. Macular amyloidosis, lichen (papular) amyloidosis, and nodular amyloidosis are three dif- ferent subtypes of PLCA. Although the pathological mechanism of PLCA has not yet been clarified, it is assumed that a nucleus formation of amyloid fibril is formed due to repeated external stimulation, such as subcutaneous injection, which often poses diagnostic chal- lenges. Herein, we present a 54-year-old Korean male patient with cutaneous localized amy- loidosis which occurred after repeated local insulin injections, and discuss the relationship between insulin therapy in patients with diabetes mellitus and dermal amyloid deposition.
참고문헌 (20)
- Shikama Y, "Localized amyloidosis at the site of repeated insulin injection in a diabetic patient", Intern Med, 49, pp.397~401 (2010)
- Nagase T, "Insulin-derived amyloidosis and poor glycemic control : a case series", Am J Med, 127, pp.450~454 (2014)
- Yumlu S, "Localized insulinderived amyloidosis in patients with diabetes mellitus : a case report", Hum Pathol, 40, pp.1655~1660 (2009)
- Swift B, "Examination of insulin injection sites : an unexpected finding of localized amyloidosis", Diabet Med, 19, pp.881~882 (2002)
- Gupta Y, "Insulin-derived amyloidosis", Indian J Endocrinol Metab, 19, pp.174~177 (2015)
- D’Souza A, "Pharmaceutical amyloidosis associated with subcutaneous insulin and enfuvirtide administration", Amyloid, 21, pp.71~75 (2014)
- Störkel S, "Iatrogenic, insulin-dependent, local amyloidosis", Lab Invest, 48, pp.108~111 (1983)
- Kikuchi M, "Ultrasonography improves glycemic control by detecting insulin-derived localized amyloidosis", Ultrasound Med Biol, 43, pp.2284~2294 (2017)
- Nilsson MR, "Insulin amyloid at injection sites of patients with diabetes", Amyloid, 23, pp.139~147 (2016)
- Merlini G, "Molecular mechanisms of amyloidosis", N Engl J Med, 349, pp.583~596 (2003)
- Landreh M, "Proinsulin C-peptide interferes with insulin fibril formation", Biochem Biophys Res Commun, 418, pp.489~493 (2012)
- Samlaska C, "Insulin-derived amyloidosis : the insulin ball, amyloidoma", JAAD Case Rep, 6, pp.351~353 (2020)
- Dische FE, "Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient", Diabetologia, 31, pp.158~161 (1988)
- Sahoo S, "Amyloid tumor : a clinical and cytomorphologic study", Diagn Cytopathol, 28, pp.325~328 (2003)
- Albert SG, "Severe insulin resistance associated with subcutaneous amyloid deposition", Diabetes Res Clin Pract, 75, pp.374~376 (2007)
- Morilla ME, "Localized amyloidosis at the site of enfuvirtide injection", Ann Intern Med, 151, pp.515~516 (2009)
- Lonsdale-Eccles AA, "Localized cutaneous amyloid at an insulin injection site", Clin Exp Dermatol, 34, pp.e1027~e1028 (2009)
- Endo JO, "Nodular amyloidosis in a diabetic patient with frequent hypoglycemia : sequelae of repeatedly injecting insulin without site rotation", J Am Acad Dermatol, 63, pp.e113~e114 (2010)
- Hagiwara S, "Localized subcutaneous insulin-derived amyloidosis excised after evaluation using ultrasonography in a patient with type 2 diabetes mellitus", Case Rep Endocrinol, 2017, pp.3985214~ (2017)
- Yakupova EI, "Congo Red and amyloids : history and relationship", Biosci Rep, 39, pp.BSR20181415~ (2019)