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시력 소실로 발현된 항중성구세포질항체 연관 비후경수막염

Two Cases of Perinuclear Anti-neutrophil Cytoplastic Antibodies Associated Hypertrophic Pachymeningitis Presented with Visual Loss

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초록

Pachymeningitis is an inflammatory process mainly involving the dura mater and is possibly associated with infectious, neoplastic, or autoimmune disease. However, in most cases, the etiology remains unknown. Clinical manifestations of pachymeningitis can vary, ranging from headache, cranial neuropathy, cerebellar dysfunction, to seizure. Here we report two cases of perinuclear anti-neutrophil cytoplasmic antibodies associated with pachymeningitis, in both the visual loss attributed to optic neuropathy was the primary sign.

Abstract

Pachymeningitis is an inflammatory process mainly involving the dura mater and is possibly associated with infectious, neoplastic, or autoimmune disease. However, in most cases, the etiology remains unknown. Clinical manifestations of pachymeningitis can vary, ranging from headache, cranial neuropathy, cerebellar dysfunction, to seizure. Here we report two cases of perinuclear anti-neutrophil cytoplasmic antibodies associated with pachymeningitis, in both the visual loss attributed to optic neuropathy was the primary sign.

참고문헌 (8)

  1. Hahn LD, "Hypertrophic pachymeningitis", J Neurol Sci, 367, pp.278~283 (2016)
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  3. Li S, "Pachymeningitis as a manifestation of ANCA-associated vasculitis : a care report and literature review", Int J Clin Exp Med, 8, pp.6352~6359 (2015)
  4. Nagashima T, "P-ANCA-positive Wegener’s granulomatosis presenting with hypertrophic pachymeningitis and multiple cranial neuropathies : case report and review of literature", Neuropathology, 20, pp.23~30 (2000)
  5. Radice A, "Antineutrophil cytoplasmic antibodies(ANCA)", Autoimmunity, 38, pp.93~103 (2005)
  6. Seo P, "The antineutrophil cytoplasmic antibody-associated vasculitides", Am J Med, 117, pp.39~50 (2004)
  7. Kitching AR, "ANCA-associated vasculitis", Nat Rev Dis Primers, 6, pp.71~ (2020)
  8. Kamisawa T, "IgG4-related disease", Lancet, 385, pp.1460~1471 (2015)

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