본문 바로가기
KERD
논문KCI 등재

장기간 고용량 졸피뎀 복용 중단 4일 이후 발생한 경련발작의 예

Seizure Occurring 4 Days after Discontinuation of Long-term High-dose Zolpidem

0

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류신경과학

초록

Zolpidem is widely used for insomnia and is known to have relatively few side effects. There have been several reports of side effects, but only a few for withdrawal symptoms. A 41-yearold woman developed convulsions 4 days after discontinuing zolpidem. She was taking more than 10 times the standard dosage. After electroencephalography monitoring without antiseizure medications, she showed no more seizures. This case highlights the danger of zolpidem withdrawal and warns about the easy accessibility of zolpidem for individuals.

Abstract

Zolpidem is widely used for insomnia and is known to have relatively few side effects. There have been several reports of side effects, but only a few for withdrawal symptoms. A 41-yearold woman developed convulsions 4 days after discontinuing zolpidem. She was taking more than 10 times the standard dosage. After electroencephalography monitoring without antiseizure medications, she showed no more seizures. This case highlights the danger of zolpidem withdrawal and warns about the easy accessibility of zolpidem for individuals.

참고문헌 (10)

  1. Morphy H, "Epidemiology of insomnia : a longitudinal study in a UK population", Sleep, 30, pp.274~280 (2007)
  2. Sanger DJ, "The pharmacology and mechanism of action of zolpidem", CNS Drug Rev, 4, pp.323~340 (1998)
  3. Holm KJ, "Zolpidem : an update of its pharmacology, therapeutic efficacy and tolerability in the treatment of insomnia", Drugs, 59, pp.865~889 (2000)
  4. Salvà P, "Clinical pharmacokinetics and pharmacodynamics of zolpidem therapeutic implications", Clin Pharmacokinet, 29, pp.142~153 (1995)
  5. McKernan RM, "Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A)receptor alpha1 subtype", Nat Neurosci, 3, pp.587~592 (2000)
  6. Liappas IA, "Zolpidem dependence case series : possible neurobiological mechanisms and clinical management", J Psychopharmacol, 17, pp.131~135 (2003)
  7. Cubała WJ, "Zolpidem abuse, dependence and withdrawal syndrome : sex as susceptibility factor for adverse effects", Br J Clin Pharmacol, 65, pp.444~445 (2008)
  8. Thomas M, "Serious adverse drug reactions to zolpidem : does impaired metabolic clearance and concurrent SSRI", SNRI use increase risk?, 2016, pp.46, 139~142
  9. Ting Xiang, "Efficacy and safety of zolpidem in the treatment of insomnia disorder for one month : a meta-analysis of a randomized controlled trial", Sleep Med, 87, pp.250~256 (2021)
  10. [URL]

관련 논문AI추천

이 간행물의 다른 논문 (16건)