치매환자에서의 심혈관계 약물사용 분석
Analysis of Cardiovascular Medication Use in Dementia Patients
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Background: Dementia is one of important social and economic healthcare issues in the aging age. Therefore, it signifies toanalyze the relationship between chronic disease or cardiovascular drug use and the incidence of dementia to establish a basis forincreasing or preventing the risk of dementia. The purpose of this study was to investigate the correlation between the prevalenceof chronic diseases and the use of cardiovascular drugs in patients diagnosed with dementia. Methods: In this study, we used datafrom sample of elderly patients from the Health Insurance Review and Assessment Service. We analyzed by logistic regressionanalysis with age, gender, and medication as covariates. KCD-7 was used to diagnosis of the disease, and drugs were analyzedusing ATC codes and Korean standardized drug classification codes. Results: A total of 1,276,331 patients were analyzed in thesample of the elderly population, of which 532,075 (41.7%) were male and 744,256 (58.3%) were female. The patients have thehigher risk of dementia in the older, women, and lower socioeconomically status. Cerebral infarction and ischemic heart diseaseincreases risk of dementia. Patients taking statins, angiotensin converting enzyme inhibitor (ACEI) or angiotensin II receptorantagonists (ARB) showed low incidence of dementia. Conclusion: This study has been shown that ACEI, ARB, and statin drugsmay associate with lower incidence of Alzheimer's and other dementia except vascular dementia.
Abstract
Background: Dementia is one of important social and economic healthcare issues in the aging age. Therefore, it signifies toanalyze the relationship between chronic disease or cardiovascular drug use and the incidence of dementia to establish a basis forincreasing or preventing the risk of dementia. The purpose of this study was to investigate the correlation between the prevalenceof chronic diseases and the use of cardiovascular drugs in patients diagnosed with dementia. Methods: In this study, we used datafrom sample of elderly patients from the Health Insurance Review and Assessment Service. We analyzed by logistic regressionanalysis with age, gender, and medication as covariates. KCD-7 was used to diagnosis of the disease, and drugs were analyzedusing ATC codes and Korean standardized drug classification codes. Results: A total of 1,276,331 patients were analyzed in thesample of the elderly population, of which 532,075 (41.7%) were male and 744,256 (58.3%) were female. The patients have thehigher risk of dementia in the older, women, and lower socioeconomically status. Cerebral infarction and ischemic heart diseaseincreases risk of dementia. Patients taking statins, angiotensin converting enzyme inhibitor (ACEI) or angiotensin II receptorantagonists (ARB) showed low incidence of dementia. Conclusion: This study has been shown that ACEI, ARB, and statin drugsmay associate with lower incidence of Alzheimer's and other dementia except vascular dementia.
참고문헌 (39)
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