관상동맥 석회 수치와 Framingham Risk Score와의 관계
The Relation of Coronary Artery Calcium Scores with Framingham Risk Scores
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연구배경: 관상동맥의 동맥경화는 폐쇄성 관상동맥 질환과 깊은 관련이 있다. 최근까지는 관상동맥 동맥경화를 반영하는 충분한 지표가 없었으나 비침습적 방법으로 관상동맥 석회 수치 검사를 이용할 수 있게 되면서 그 활용도가 늘어나고 있다. 한편 Framingham risk score는 심혈관 질환의 위험도를 평가하는 전통적인 지침으로 자리잡고 있다. 본 단면 연구에서는 관상동맥 석회 수치와 Framingham risk score와의 관련성을 알아보고자 한다. 방법: 2005년 1월 5일부터 2006년 8월 12일까지 세브란스 병원 가정의학과에 입원 및 외래 방문한 환자 중 관상동맥 석회 수치 검사를 시행한 사람 135명을 대상으로, 성별, 연령, 수축기 혈압, 총콜레스테롤, 고밀도지단백콜레스테롤 등을 바탕으로 Framingham risk score를 계산하였다. 관상동맥 석회 수치와 Framingham risk score와의 상관 관계를 분석하고 관상동맥 석회 수치를 분획하여 각 그룹의 차이를 검정하였다. 결과: 관상동맥 석회 수치와 10년 위험도와의 상관계수는 0.282 (P<0.01)이었으며, 남자의 경우 의미있는 관련성을 발견할 수 없었으나, 여자의 경우 상관계수 0.349 (P<0.01)로 분명한 상관관계를 보였다. 분획하여 검정한 결과 관상동맥 석회 수치가 0인 경우와 1 이상인 경우에서 10년 위험도가 의미 있는 차이를 보였으나(P<0.001), 1∼99인 그룹과 100 이상인 그룹 사이에는 의미있는 차이를 보이지 않았다. 결론: 관상동맥 석회 수치와 Framingham risk score와는 양의 상관관계를 보였으며, 석회 수치가 0인 경우보다 1 이상인 경우에 그 위험도는 의미있게 증가한다. 관상동맥 석회 수치는 심혈관계 위험도를 평가하는데 의미있는 요소이다.
Abstract
Background: Atherosclerosis of the coronary artery is related to the obstructive coronary artery disease. The coronary artery calcium score test is a non-invasive and useful indicator of atherosclerosis. The Framingham risk scoring system is a traditional indicator of the cardiovascular risk. This cross-sectional study was performed to evaluate the relation of the coronary artery calcium scores with Framingham risk scores. Methods: We evaluated 135 patients who visited the Department of Family Medicine in Severance Hospital and had a test of the coronary artery calcium scores from January 5th, 2005, to August 12th, 2006. The Framingham risk scores were calculated. We analyzed the correlation between the coronary artery calcium scores and the Framingham risk scores and tested the difference between the groups divided by categorization of the calcium scores. Results: The coronary artery calcium scores were significantly correlated with the Framingham risk scores (r=0.282, P<0.01). There was a significant correlation in case of women (r=0.349, P<0.01), but not in case of men. There was a significant difference between the group whose calcium score was 0 and the group whose calcium scores were above 0 (P<0.001). Conclusion: There was a positive correlation between the coronary artery calcium scores and the Framingham risk scores. The coronary artery calcium score seems to be a significant factor to assess the cardiovascular risk.
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