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체중과 골밀도 -역학적 근거의 정리-

Weight and Bone Mineral Density - The Summary of Epidemiological Evidence -

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초록

체중은 골밀도에 영향을 미칠 뿐만 아니라, 체중변화 역시 골밀도 변화에 영향을 미친다. 체중변화로 인한 골밀도 변화 는, 남성보다 여성에서, 폐경전 여성보다는 폐경후 여성에서, 나이가 많을수록, 비만도가 낮을 수록, 체중감소와 증가를 반 복한 과거력이 있는 사람에서 더 크게 나타난다. 체중감소로 인한 골밀도 감소를 줄이기 위한 중재방법들로, 여성호르몬 치료, 랄록시펜, 운동, 칼슘보충제의 복용 등이 제시되고 있다. 본 종설에서는 체중과 골밀도, 골절의 관련성과 그 관련성에 영향을 미치는 요인들에 대해 지금까지 발표된 국내외 연구 들을 정리해 보고자 한다.

Abstract

Not only bone mineral density (BMD) is strongly associated with body weight, but also weight change infl uences BMD change. The weight change related bone change is more marked in women especially after menopause, in the elderly, in the underweight and in persons who have the history of weight cycling. Because of the health impacts of obesity, weight reduction has been often recommended in practices. Therefore various intervention methods have been tried to reduce the weight change related bone change such as hormone therapy, raloxifene, exercise, and calcium supplementation. This review summarizes the epidemiological evidences of the weight change related bone change and the associated factors.

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