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Lucio Phenomenon: Sequelae of Neglected Leprosy

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초록

Lucio phenomenon is a potentially fatal leprosy reaction seen in pure, primitive, and diffuse form of lepromatous leprosy. It is a globally restricted phenomenon that occurs in Mexico and Costa Rica; however, sporadic cases have been reported elsewhere. We report a rare case of a 50-year-old Indonesian, who resided in Malaysia for the past 33 years, which presented with extensive ulcers on all four limbs for 3 weeks, as well as a 16-year history of skin changes and alopecia. Full evaluation established the diagnosis of lepromatous leprosy with Lucio phenomenon. Delay in diagnosis leads to significant disabilities and disease transmission within the community. Therefore, primary care practitioners, even in non-endemic countries, should be wary of this atypical feature of leprosy to prevent complications since it is a highly curable disease.

Abstract

Lucio phenomenon is a potentially fatal leprosy reaction seen in pure, primitive, and diffuse form of lepromatous leprosy. It is a globally restricted phenomenon that occurs in Mexico and Costa Rica; however, sporadic cases have been reported elsewhere. We report a rare case of a 50-year-old Indonesian, who resided in Malaysia for the past 33 years, which presented with extensive ulcers on all four limbs for 3 weeks, as well as a 16-year history of skin changes and alopecia. Full evaluation established the diagnosis of lepromatous leprosy with Lucio phenomenon. Delay in diagnosis leads to significant disabilities and disease transmission within the community. Therefore, primary care practitioners, even in non-endemic countries, should be wary of this atypical feature of leprosy to prevent complications since it is a highly curable disease.

참고문헌 (10)

  1. Choon SE, "Lucio’s phenomenon: a report of three cases seen in Johor, Malaysia", Int J Dermatol, 48, pp.984~988 (2009)
  2. Monteiro R, "Lucio’s phenomenon: another case reported in Brazil", An Bras Dermatol, 87, pp.296~300 (2012)
  3. Ang P, "Fatal Lucio’s phenomenon in 2 patients with previously undiagnosed leprosy", J Am Acad Dermatol, 48, pp.958~961 (2003)
  4. Curi PF, "Lucio’s phenomenon : report of five cases", Clin Rheumatol, 35, pp.1397~1401 (2016)
  5. Vera-Cabrera L, "Case of diffuse lepromatous leprosy associated with"Mycobacterium lepromatosis"", J Clin Microbiol, 49, pp.4366~4368 (2011)
  6. Kaur C, "Lucio phenomenon and Lucio leprosy", Clin Exp Dermatol, 30, pp.525~527 (2005)
  7. Velarde-Felix JS, ""Lucio’s phenomenon"associated with mycobacterium lepromatosis", Am J Trop Med Hyg, 94, pp.483~484 (2016)
  8. Rea TH, "Clinical and histologic variations among thirty patients with Lucio’s phenomenon and pure and primitive diffuse lepromatosis(Latapi’s lepromatosis)", Int J Lepr Other Mycobact Dis, 73, pp.169~188 (2005)
  9. Kwan Z, "Leprosy : an imported disease", Lepr Rev, 85, pp.170~176 (2014)
  10. World Health Organization, "Global Leprosy Strategy 2016–2020: accelerating towards a leprosy-free world", World Health Organization India, ~ (2016)

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