30대 직장 남성의 우울 성향이 심장에 대한 자율신경 조절 기능에 미치는 영향
The Influence of Depression on Cardiac Autonomous Control in the Thirties Male Workers
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연구배경: 이 연구는 30대 직장 남성에서 보이는 우울 성향이 심장에 대한 자율신경 조절 기능에 미치는 영향을 알아보고자 하였다. 방법: 2002년 6월에서 7월까지 종합건강검진을 받은 일개 직장의 30대 남성 중 특이 병력이 없는 85명을 대상으로 하였다. 연령, 키, 체중, 혈압, 음주 및 흡연력, 규칙적인 운동 여부와 함께 자가-기입식 설문지인 Zung의 Self-rating Depression Scale (SDS)을 이용하여 우울 성향을 평가하였다. 심박동변이는 5분 동안의 심전도 기록을 시간 범주인 Standard Deviation of NN intervals (SDNN), Root-Mean-Square of Successive Differences (RMSSD)와 주파수 범주인 Total Power (TP), Low Frequency (LF: 0.04~0.15 Hz) power, High Frequency (HF: 0.15~0.4 Hz) power, LF/HF 비로 나누어 분석하였다. 결과: 심박동변이 측정치와 생활 습관 및 임상 변수들과의 다변량 분석 결과, 평균 심박수와 SDS 지수가 심박동변이의 시간 범주의 측정치(SDNN, RMSSD) 및 주파수 범주 측정치(TP, LF, HF)와 모두 관련이 있는 것으로 나타났다. SDS 지수에 따라 우울성향군(SDS index ≥53, n=15)과 비우울군(SDS index <53, n=70)으로 분류한 후 평균 심박수를 공변량으로 하여 공분산분석을 시행한 결과, 우울성향군이 비우울군에 비해 심박동변이(SDNN, RMSSD, TP, LF, HF) 값이 유의하게 감소하는 것으로 나타났다. LF/HF 비는 우울성향군과 비우울군 사이에 유의한 차이를 보이지 않았다. 결론: 30대 직장 남성의 우울 성향이 심박동변이의 감소와 연관이 있다는 것은 심장에 대한 자율신경계 조절의 이상을 반영하며, 이들에게서 심혈관 질환의 위험이 증가할 수 있음을 의미한다. 그러나 향후에는 잘 계획된 전향적 연구를 통하여 이에 대한 확인이 필요할 것이다.
Abstract
Background: The purpose of this study was to investigate the relationship between depression and heart rate variability in the thirties male workers. Methods: Subjects were 85 thirties male workers who had routine health examination from June to July in 2002. They were classified as the depressed group (n=15) or the non-depressed group (n=70) on the basis of Zung Self-rating Depression Scale (SDS) index. 5- minute electrocardiographic (ECG) recordings were analyzed with time and frequency domain methods of heart rate variability (HRV). Standard Deviation of NN intervals (SDNN), Root-Mean-Square of Successive Differences (RMSSD), Total Power (TP), Low Frequency (LF: 0.04~0.15 Hz) power, High Frequency (HF: 0.15~0.4 Hz) power, LF/HF ratio were used as the indices of HRV. The data were analyzed using SPSS 11.0/PC program. Results: There were no significant differences among the groups in drinking, smoking, body mass index (BMI), or exercise. Heart rate variability (SDNN, rMSSD, TP, LF, HF) was significantly lower in the depressed group than in the non-depressed group. Mean heart rate was also higher in the depressed group compared with the non-depressed group, but these differences did not attain statistical significance. Conclusions: The association of depressed mood with reduced heart rate variability in the thirties male workers reflect dysregulation of cardiac autonomous control and may explain their increased risk for cardiovascular disease. However, we should confirm those effects through the well-designed prospective study.
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