Association of Serum Total Bilirubin with Serum High Sensitivity C-reactive Protein in Middle-aged Men
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: It has been suggested that bilirubin has an inverse association with cardiovascular disease (CVD) due to its antioxidant properties. However, there are few data regarding the relationship between serum total bilirubin (sTB) and risk factors for CVD in Koreans. This study aimed to evaluate the relationship between sTB and high sensitivity C-reactive protein (hsCRP), which is an independent risk factor for CVD. Methods: We performed a cross sectional study in 6,800 men who were examined at a health promotion center at a university hospital in Korea between May 2005 and June 2006. We grouped the subjects according to values of serum hsCRP (above or below 1.0 mg/L) and compared the characteristics of the two groups. To evaluate the relationship between sTB and hsCRP, we classifi ed the subjects according to quartile values of sTB. Multivariate logistic regression analyses were used to analyze the relationship of levels of sTB and hsCRP after adjusting for known risk factors for CVD. Results: Serum hsCRP was signifi cantly associated with body mass index (BMI), smoking, diabetes, hypertension, fasting plasma glucose, systolic blood pressure, alanine aminotransferase, and total cholesterol/high density lipoprotein (TC/HDL-C) ratio, but not with age or alcohol use. As levels of sTB increased, there was a decrease in age, numbers of smokers,BMI, and TC/HDL ratio. Compared to the lowest quartile of sTB, levels of hsCRP decreased with odds ratios of 0.82 (95%CI, 0.71 to 0.96), 0.75 (95% CI, 0.65 to 0.88), and 0.63 (95% CI, 0.54 to 0.74) in the 2nd, 3rd, and 4th quartiles of bilirubin,respectively. Conclusion: Bilirubin may be inversely associated with hsCRP
Abstract
Background: It has been suggested that bilirubin has an inverse association with cardiovascular disease (CVD) due to its antioxidant properties. However, there are few data regarding the relationship between serum total bilirubin (sTB) and risk factors for CVD in Koreans. This study aimed to evaluate the relationship between sTB and high sensitivity C-reactive protein (hsCRP), which is an independent risk factor for CVD. Methods: We performed a cross sectional study in 6,800 men who were examined at a health promotion center at a university hospital in Korea between May 2005 and June 2006. We grouped the subjects according to values of serum hsCRP (above or below 1.0 mg/L) and compared the characteristics of the two groups. To evaluate the relationship between sTB and hsCRP, we classifi ed the subjects according to quartile values of sTB. Multivariate logistic regression analyses were used to analyze the relationship of levels of sTB and hsCRP after adjusting for known risk factors for CVD. Results: Serum hsCRP was signifi cantly associated with body mass index (BMI), smoking, diabetes, hypertension, fasting plasma glucose, systolic blood pressure, alanine aminotransferase, and total cholesterol/high density lipoprotein (TC/HDL-C) ratio, but not with age or alcohol use. As levels of sTB increased, there was a decrease in age, numbers of smokers,BMI, and TC/HDL ratio. Compared to the lowest quartile of sTB, levels of hsCRP decreased with odds ratios of 0.82 (95%CI, 0.71 to 0.96), 0.75 (95% CI, 0.65 to 0.88), and 0.63 (95% CI, 0.54 to 0.74) in the 2nd, 3rd, and 4th quartiles of bilirubin,respectively. Conclusion: Bilirubin may be inversely associated with hsCRP
참고문헌 (27)
- Ross R, "Atherosclerosis: an inflammatory disease", N Engl J Med, 340, pp.115~126 (1999)
- Tomoda H, "Prognostic value of C-reactive protein levels within six hours after the onset of acute myocardial infarction", Am Heart J, 140, pp.324~328 (2000)
- Ridker PM, "Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk", Circulation, 109, pp.2818~2825 (2004)
- Ridker PM, "Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men", N Engl J Med, 336, pp.973~979 (1997)
- Ridker PM, "C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction", Circulation, 97, pp.2007~2011 (1998)
- Ridker PM, "C-reactive protein and other markers of infl ammation in the prediction of cardiovascular disease in women", N Engl J Med, 342, pp.836~843 (2000)
- Schwertner HA, "Association of low serum concentration of bilirubin with increased risk of coronary artery disease", Clin Chem, 40, pp.18~23 (1994)
- Hunt SC, "Evidence for a major gene elevating serum bilirubin concentration in Utah pedigrees", Arterioscler Th romb Vasc Biol, 16, pp.912~917 (1996)
- 문준성, "제2형 당뇨병환자에게서 혈청 빌리루빈과 관상동맥 죽상경화증의 관계", Diabetes and Metabolism Journal, 32(4), pp.338~345 (2008), 대한당뇨병학회
- Libby P, "Infl ammation and atherosclerosis: role of C-reactive protein in risk assessment", Am J Med, 116(6A), pp.9S~16S (2004)
- Djousse L, "Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study", Am J Cardiol, 87, pp.1196~1200 (2001)
- Djousse L, "Effect of serum albumin and bilirubin on the risk of myocardial infarction (the Framingham Offspring Study)", Am J Cardiol, 91, pp.485~488 (2003)
- Perlstein TS, "Serum total bilirubin level, prevalent stroke, and stroke outcomes: NHANES 1999-2004", Am J Med, 121, pp.781~788 (2008)
- Novotny L, "Inverse relationship between serum bilirubin and atherosclerosis in men: a meta-analysis of published studies", Exp Biol Med (Maywood), 228, pp.568~571 (2003)
- Vitek L, "Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels", Atherosclerosis, 160, pp.449~456 (2002)
- Nakanishi N, "Association between fasting glucose and C-reactive protein in a Japanese population: the Minoh study", Diabetes Res Clin Pract, 69, pp.88~98 (2005)
- 나은희, "건강검진에서 공복혈당에 따른 고감도 C-반응성 단백질과 대사증후군과의 관계", Annals of Laboratory Medicine, 26(6), pp.454~459 (2006), 대한진단검사의학회
- 조양현, "한국 성인에서의 음주와 hsCRP의 관련성", Korean Journal of Family Medicine, 28(10), pp.768~773 (2007), 대한가정의학회
- Albert MA, "Alcohol consumption and plasma concentration of C-reactive protein", Circulation, 107, pp.443~447 (2003)
- Imhof A, "Effect of alcohol consumption on systemic markers of infl ammation", Lancet, 357, pp.763~767 (2001)
- Van Hoydonck PG, "Serum bilirubin concentration in a Belgian population: the association with smoking status and type of cigarettes", Int J Epidemiol, 30, pp.1465~1472 (2001)
- Madhavan M, "Serum bilirubin distribution and its relation to cardiovascular risk in children and young adults", Atherosclerosis, 131, pp.107~113 (1997)
- 진호준, "The Bilirubin Level is Negatively Correlated with the Incidence of Hypertension in Normotensive Korean Population", Journal of Korean Medical Science, 24, pp.50~56 (2009), 대한의학회
- Wu TW, "Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins", Biochem Pharmacol, 51, pp.859~862 (1996)
- Ollinger R, "Bilirubin: a natural inhibitor of vascular smooth muscle cell proliferation", Circulation, 112, pp.1030~1039 (2005)
- Ollinger R, "Bilirubin and biliverdin treatment of atherosclerotic diseases", Cell Cycle, 6, pp.39~43 (2007)
- Neuzil J, "Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation", J Biol Chem, 269, pp.16712~16719 (1994)