The Association between Atopic Dermatitis and Depressive Symptoms in Korean Adults: The Fifth Korea National Health and Nutrition Examination Survey, 2007–2012
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Background: Atopic dermatitis (AD) is characterized by pruritic and eczematous skin lesions, which often cause depressive symptoms, anxiety, stress, sleep disturbances, social withdrawal, and stigmatization. Methods: In total, 23,442 subjects (434 AD patients and 23,008 control subjects) aged 19 years or older and without a history of major medical illness or depressive disorders were selected from The Fifth Korea National Health and Nutrition Examination Survey 2007–2012. Following the initial selection, 2,170 age- and sex-matched control subjects were selected using 1:5 propensity score matching. Multiple logistic regression analysis was performed to identify the presence of depressive symptoms of at least 2 weeks in duration. Results: The demographic, socioeconomic, and clinical characteristics of AD patients and control subjects were presented and compared, and some variables differed significantly between groups. Presence of depressive symptoms was set as dependent variable, and multiple logistic regression analysis was performed as follows: (1) unadjusted; (2) with alcohol use, exercise status, smoking status, and body mass index (BMI) adjusted for; and (3) with alcohol use, exercise status, smoking status, marital status, occupation, BMI, total caloric intake, history of hypertension, and history of diabetes mellitus adjusted for. Depressive symptoms were significantly higher (odds ratios, 1.46, 1.40, and 1.36; 95% confidence intervals, 1.09–1.95, 1.0.4–1.88, and 1.01–1.85, respectively) in AD patients relative to those of matched controls. Conclusion: AD and clinical depression interact closely, and causal relationships between the two conditions have frequently been observed. Physicians should consider mental health interventions cautiously. It is particularly important that primary care physicians provide comprehensive, continuous long-term care.
Abstract
Background: Atopic dermatitis (AD) is characterized by pruritic and eczematous skin lesions, which often cause depressive symptoms, anxiety, stress, sleep disturbances, social withdrawal, and stigmatization. Methods: In total, 23,442 subjects (434 AD patients and 23,008 control subjects) aged 19 years or older and without a history of major medical illness or depressive disorders were selected from The Fifth Korea National Health and Nutrition Examination Survey 2007–2012. Following the initial selection, 2,170 age- and sex-matched control subjects were selected using 1:5 propensity score matching. Multiple logistic regression analysis was performed to identify the presence of depressive symptoms of at least 2 weeks in duration. Results: The demographic, socioeconomic, and clinical characteristics of AD patients and control subjects were presented and compared, and some variables differed significantly between groups. Presence of depressive symptoms was set as dependent variable, and multiple logistic regression analysis was performed as follows: (1) unadjusted; (2) with alcohol use, exercise status, smoking status, and body mass index (BMI) adjusted for; and (3) with alcohol use, exercise status, smoking status, marital status, occupation, BMI, total caloric intake, history of hypertension, and history of diabetes mellitus adjusted for. Depressive symptoms were significantly higher (odds ratios, 1.46, 1.40, and 1.36; 95% confidence intervals, 1.09–1.95, 1.0.4–1.88, and 1.01–1.85, respectively) in AD patients relative to those of matched controls. Conclusion: AD and clinical depression interact closely, and causal relationships between the two conditions have frequently been observed. Physicians should consider mental health interventions cautiously. It is particularly important that primary care physicians provide comprehensive, continuous long-term care.
참고문헌 (13)
- Oh SH, "Association of stress with symptoms of atopic dermatitis", Acta Derm Venereol, 90, pp.582~588 (2010)
- Ahn SG, "Common skin disease of Koreans" (2009), Doctor’s Book
- Senra MS, "Psychodermatological aspects of atopic dermatitis", Br J Dermatol, 170(Suppl 1), pp.38~43 (2014)
- Yaghmaie P, "Mental health comorbidity in patients with atopic dermatitis", J Allergy Clin Immunol, 131, pp.428~433 (2013)
- Dalgard FJ, "The psychological burden of skin diseases: a cross-sectional multicenter study among dermatological out-patients in 13 European countries", J Invest Dermatol, 135, pp.984~991 (2015)
- Simpson EL., "Comorbidity in atopic dermatitis", Curr Dermatol Rep, 1, pp.29~38 (2012)
- Bockelbrink A, "Atopic eczema in children: another harmful sequel of divorce", Allergy, 61, pp.1397~1402 (2006)
- Gupta MA, "Depression modulates pruritus perception: a study of pruritus in psoriasis, atopic dermatitis and chronic idiopathic urticaria", Ann N Y Acad Sci, 885, pp.394~395 (1999)
- Garg A, "Psychological stress perturbs epidermal permeability barrier homeostasis:implications for the pathogenesis of stress-associated skin disorders", Arch Dermatol, 137, pp.53~59 (2001)
- Hashizume H, "Anxiety accelerates T-helper 2-tilted immune responses in patients with atopic dermatitis", Br J Dermatol, 152, pp.1161~1164 (2005)
- Slattery MJ, "Depression, anxiety, and dermatologic quality of life in adolescents with atopic dermatitis", J Allergy Clin Immunol, 128, pp.668~671 (2011)
- Ando T, "Development and validation of the psychosomatic scale for atopic dermatitis in adults", J Dermatol, 33, pp.439~450 (2006)
- Kelsay K, "Addressing psychosocial aspects of atopic dermatitis", Immunol Allergy Clin North Am, 30, pp.385~396 (2010)