Sarcopenia Is Not Associated with Depression in Korean Adults: Results from the 2010–2011 Korean National Health and Nutrition Examination Survey
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Background: Sarcopenia is associated with metabolic disorders, cardiovascular disease, and mortality; however, its association with depression in the general population remains unknown. Therefore, we investigated this association in Korea. Methods: This study included 8,958 and 8,518 subjects from the 2010–2011 Korean National Health and Nutrition Examination Survey V-1, 2. The study was restricted to participants ≥20 years of age who had completed the survey, including whole-body dual-energy X-ray absorptiometry scans. After exclusion, 7,364 subjects were included in our final analysis. Age was categorized into three groups (20–39, 40–59, and ≥60 years), and subjects were categorized according to their sarcopenic and obesity status. Depression was categorized into three groups (not depressed, depressed, and depression). Results: The sarcopenia group did not have a higher prevalence of depression or depressive symptoms compared to the nonsarcopenia group; the same was true even when obesity was considered. All age groups showed non-significant associations between sarcopenia and depression. In multivariate logistic regression models, no significant associations were observed between sarcopenia and prevalence of depression or depressed symptoms in men and women. Conclusion: We found no associations between sarcopenia and the prevalence of depression or depressed symptoms in Korean adults. Future large prospective studies and randomized controlled trials are needed to further assess this relationship.
Abstract
Background: Sarcopenia is associated with metabolic disorders, cardiovascular disease, and mortality; however, its association with depression in the general population remains unknown. Therefore, we investigated this association in Korea. Methods: This study included 8,958 and 8,518 subjects from the 2010–2011 Korean National Health and Nutrition Examination Survey V-1, 2. The study was restricted to participants ≥20 years of age who had completed the survey, including whole-body dual-energy X-ray absorptiometry scans. After exclusion, 7,364 subjects were included in our final analysis. Age was categorized into three groups (20–39, 40–59, and ≥60 years), and subjects were categorized according to their sarcopenic and obesity status. Depression was categorized into three groups (not depressed, depressed, and depression). Results: The sarcopenia group did not have a higher prevalence of depression or depressive symptoms compared to the nonsarcopenia group; the same was true even when obesity was considered. All age groups showed non-significant associations between sarcopenia and depression. In multivariate logistic regression models, no significant associations were observed between sarcopenia and prevalence of depression or depressed symptoms in men and women. Conclusion: We found no associations between sarcopenia and the prevalence of depression or depressed symptoms in Korean adults. Future large prospective studies and randomized controlled trials are needed to further assess this relationship.
참고문헌 (29)
- Peveler R, "Depression in medical patients", BMJ, 325, pp.149~152 (2002)
- Shim RS, "Prevalence, treatment, and control of depressive symptoms in the United States: results from the National Health and Nutrition Examination Survey (NHANES), 2005-2008", J Am Board Fam Med, 24, pp.33~38 (2011)
- Bromet E, "Cross-national epidemiology of DSM-IV major depressive episode", BMC Med, 9, pp.90~ (2011)
- The epidemiological survey of mental disorders in Korea 2011, "Seoul National University College of Medicine", Ministry of Health and Welfare, ~ (2012)
- Chang SM, "Cross-national difference in the prevalence of depression caused by the diagnostic threshold", J Affect Disord, 106, pp.159~167 (2008)
- Rosenberg IH, "Sarcopenia: origins and clinical relevance", J Nutr, 127(5 Suppl), pp.990S~991S (1997)
- Baumgartner RN, "Epidemiology of sarcopenia among the elderly in New Mexico", Am J Epidemiol, 147, pp.755~763 (1998)
- Bijlsma AY, "Chronology of agerelated disease definitions: osteoporosis and sarcopenia", Ageing Res Rev, 11, pp.320~324 (2012)
- Janssen I, "The healthcare costs of sarcopenia in the United States", J Am Geriatr Soc, 52, pp.80~85 (2004)
- Janssen I, "Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability", J Am Geriatr Soc, 50, pp.889~896 (2002)
- Stenholm S, "Sarcopenic obesity: definition, cause and consequences", Curr Opin Clin Nutr Metab Care, 11, pp.693~700 (2008)
- Cole MG, "Risk factors for depression among elderly community subjects: a systematic review and meta-analysis", Am J Psychiatry, 160, pp.1147~1156 (2003)
- Luppino FS, "Overweight, obesity, and depression: a systematic review and metaanalysis of longitudinal studies", Arch Gen Psychiatry, 67, pp.220~229 (2010)
- Cho Y, "Sarcopenic obesity is associated with lower indicators of psychological health and quality of life in Koreans", Nutr Res, 35, pp.384~392 (2015)
- Kim NH, "Depression is associated with sarcopenia, not central obesity, in elderly korean men", J Am Geriatr Soc, 59, pp.2062~2068 (2011)
- Hsu YH, "Association of cognitive impairment, depressive symptoms and sarcopenia among healthy older men in the veterans retirement community in southern Taiwan: a cross-sectional study", Geriatr Gerontol Int, 14(Suppl 1), pp.102~108 (2014)
- The fifth Korea National Health and Nutrition Examination Survey (KNHANES V-1, 2)2010–2011, "Korea Centers for Disease Control and Prevention", Korea Centers for Disease Control and Prevention, ~ (2010)
- 구슬, "한국 성인의 혈청 25(OH)D 수준과 우울증 및 우울증상 경험과의 연관성: 국민건강영양조사 2008-2010 분석 결과", Journal of Nutrition and Health, 47(2), pp.113~123 (2014), 한국영양학회
- Muscaritoli M, "Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics”", Clin Nutr, 29, pp.154~159 (2010)
- Moon SS, "Low skeletal muscle mass is associated with insulin resistance, diabetes, and metabolic syndrome in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES)2009-2010", Endocr J, 61, pp.61~70 (2014)
- Grundy SM, "Diagnosis and management of the metabolic syndrome: an American Heart Association", National Heart, Lung, and Blood Institute Scientific Statement, 2005, pp.112, 2735~2752
- Lee SY, "Appropriate waist circumference cutoff points for central obesity in Korean adults", Diabetes Res Clin Pract, 75, pp.72~80 (2007)
- Lee JS, "Associated factors and health impact of sarcopenia in older chinese men and women:a cross-sectional study", Gerontology, 53, pp.404~410 (2007)
- Jensen GL, "Inflammation: roles in aging and sarcopenia", J Parenter Enteral Nutr, 32, pp.656~659 (2008)
- Baune BT, "Inflammatory biomarkers predict depressive, but not anxiety symptoms during aging: the prospective Sydney Memory and Aging Study", Psychoneuroendocrinology, 37, pp.1521~1530 (2012)
- Meng SJ, "Oxidative stress, molecular inflammation and sarcopenia", Int J Mol Sci, 11, pp.1509~1526 (2010)
- Nataliia Bakunina, "Immune mechanisms linked to depression via oxidative stress and neuroprogression", Immunology (2015), Wiley-Blackwell[DOI]
- Maggio M, "Sex hormones and sarcopenia in older persons", Curr Opin Clin Nutr Metab Care, 16, pp.3~13 (2013)
- Zarrouf FA, "Testosterone and depression:systematic review and meta-analysis", J Psychiatr Pract, 15, pp.289~305 (2009)