Association between Relative Handgrip Strength and Insulin Resistance in Korean Elderly Men without Diabetes: Findings of the 2015 Korea National Health Nutrition Examination Survey
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Background: Evidence regarding the association between handgrip strength (HGS) and insulin resistance in a non-diabetic population is scarce. This study aimed to investigate the association between relative HGS and insulin resistance in older men without diabetes, using a representative sample of the Korean male population.Methods: The study population comprised 206 participants aged 65–80 years, selected from the 2015 Korea Na-tional Health and Nutrition Examination Survey. Insulin resistance was defined as the upper tertile of the homeo-static model assessment of insulin resistance (HOMA-IR). Odds ratios and 95% confidence intervals for insulin re-sistance were assessed using multiple logistic regression analyses after adjusting for confounding variables.Results: The prevalence of insulin resistance decreased with increasing relative HGS. The prevalence in the T1, T2, and T3 groups was 46.0%, 32.2%, and 26.4%, respectively. Compared with the individuals in the highest tertile of relative HGS, the odds ratio (95% confidence interval) for insulin resistance in individuals in the lowest quartile was 2.82 (1.10–7.21) after adjusting for age, smoking, alcohol consumption, aerobic exercise, resistance exercise, systolic blood pressure, total cholesterol, residential area, household income, and education level.Conclusion: Lower relative HGS was inversely associated with an increased risk of insulin resistance in older Kore-an men without diabetes. In clinical practice, relative HGS, which is a simple and inexpensive tool, could be a use-ful measure for identifying older men with insulin resistance. Moreover, these findings suggest that muscle strengthening exercises should be considered to reduce insulin resistance and increase insulin sensitivity.
Abstract
Background: Evidence regarding the association between handgrip strength (HGS) and insulin resistance in a non-diabetic population is scarce. This study aimed to investigate the association between relative HGS and insulin resistance in older men without diabetes, using a representative sample of the Korean male population.Methods: The study population comprised 206 participants aged 65–80 years, selected from the 2015 Korea Na-tional Health and Nutrition Examination Survey. Insulin resistance was defined as the upper tertile of the homeo-static model assessment of insulin resistance (HOMA-IR). Odds ratios and 95% confidence intervals for insulin re-sistance were assessed using multiple logistic regression analyses after adjusting for confounding variables.Results: The prevalence of insulin resistance decreased with increasing relative HGS. The prevalence in the T1, T2, and T3 groups was 46.0%, 32.2%, and 26.4%, respectively. Compared with the individuals in the highest tertile of relative HGS, the odds ratio (95% confidence interval) for insulin resistance in individuals in the lowest quartile was 2.82 (1.10–7.21) after adjusting for age, smoking, alcohol consumption, aerobic exercise, resistance exercise, systolic blood pressure, total cholesterol, residential area, household income, and education level.Conclusion: Lower relative HGS was inversely associated with an increased risk of insulin resistance in older Kore-an men without diabetes. In clinical practice, relative HGS, which is a simple and inexpensive tool, could be a use-ful measure for identifying older men with insulin resistance. Moreover, these findings suggest that muscle strengthening exercises should be considered to reduce insulin resistance and increase insulin sensitivity.
참고문헌 (36)
- Lebovitz HE, "Insulin resistance : definition and consequences", Exp Clin Endocrinol Diabetes, 109(Suppl 2), pp.S135~S148 (2001)
- Taylor R, "Insulin resistance and type 2 diabetes", Diabetes, 61, pp.778~779 (2012)
- Govender N, "Insulin resistance in COVID-19 and diabetes", Prim Care Diabetes, 15, pp.629~634 (2021)
- Holscher C, "Brain insulin resistance : role in neurodegenerative disease and potential for targeting", Expert Opin Investig Drugs, 29, pp.333~348 (2020)
- Du XP, "Relationship between insulin resistance and clustering of risk factors of cerebrovascular disease", Hunan Yi Ke Da Xue Xue Bao, 25, pp.163~165 (2000)
- McFarlane SI, "Insulin resistance and cardiovascular disease", J Clin Endocrinol Metab, 86, pp.713~718 (2001)
- Arcidiacono B, "Insulin resistance and cancer risk : an overview of the pathogenetic mechanisms", Exp Diabetes Res, 2012, pp.789174~ (2012)
- Ausk KJ, "Insulin resistance predicts mortality in nondiabetic individuals in the U. S", Diabetes Care, 33, pp.1179~1185 (2010)
- Kontis V, "Future life expectancy in 35 industrialised countries : projections with a Bayesian model ensemble", Lancet, 389, pp.1323~1335 (2017)
- Ryan AS, "Insulin resistance with aging : effects of diet and exercise", Sports Med, 30, pp.327~346 (2000)
- Shou J, "Mechanism of increased risk of insulin resistance in aging skeletal muscle", Diabetol Metab Syndr, 12, pp.14~ (2020)
- Rodriguez-Manas L, "Dual effects of insulin resistance on mortality and function in non-diabetic older adults : findings from the Toledo Study of Healthy Aging", Geroscience (2021)[DOI]
- de Boer IH, "Insulin resistance, cystatin C, and mortality among older adults", Diabetes Care, 35, pp.1355~1360 (2012)
- Blanquet M, "Handgrip strength as a valid practical tool to screen early-onset sarcopenia in acute care wards : a first evaluation", Eur J Clin Nutr, 76, pp.56~64 (2022)
- Kim M, "Sarcopenia in Korean community-dwelling adults aged 70 years and older : application of screening and diagnostic tools from the Asian working group for sarcopenia 2019 update", J Am Med Dir Assoc, 21, pp.752~758 (2020)
- Hardy R, "Body mass index, muscle strength and physical performance in older adults from eight cohort studies : the HALCyon programme", PLoS One, 8, pp.e56483~ (2013)
- Chon D, "Consideration of body mass index(BMI)in the association between hand grip strength and hypertension : Korean Longitudinal Study of Ageing(KLoSA)", PLoS One, 15, pp.e0241360~ (2020)
- 김보미, "Association between Relative Handgrip Strength and Dyslipidemia in Korean Adults: Findings of the 2014–2015 Korea National Health and Nutrition Examination Survey", Korean Journal of Family Medicine, 41(6), pp.404~411 (2020), 대한가정의학회[DOI]
- 김상욱, "Low Handgrip Strength is Associated with Low Bone Mineral Density and Fragility Fractures in Postmenopausal Healthy Korean Women", Journal of Korean Medical Science, 27(7), pp.744~747 (2012), 대한의학회[DOI]
- Yi DW, "Relative handgrip strength as a marker of metabolic syndrome : the Korea National Health and Nutrition Examination Survey(KNHANES)VI(2014-2015)", Diabetes Metab Syndr Obes, 11, pp.227~240 (2018)
- Jang JY, "Association between handgrip strength and cognitive impairment in elderly Koreans : a population-based cross-sectional study", J Phys Ther Sci, 27, pp.3911~3915 (2015)
- Bae EJ, "Handgrip strength and all-cause mortality in middle-aged and older Koreans", Int J Environ Res Public Health, 16, pp.740~ (2019)
- 박혜선, "Determinants of Bone Mass and Insulin Resistance in Korean Postmenopausal Women: Muscle Area, Strength, or Composition?", Yonsei Medical Journal, 60(8), pp.742~750 (2019), 연세대학교의과대학[DOI]
- Sayer AA, "Grip strength and the metabolic syndrome : findings from the Hertfordshire Cohort Study", QJM, 100, pp.707~713 (2007)
- Lawman HG, "Associations of relative handgrip strength and cardiovascular disease biomarkers in U. S. adults, 2011-2012", Am J Prev Med, 50, pp.677~683 (2016)
- Yang EJ, "Association between muscle strength and metabolic syndrome in older Korean men and women : the Korean Longitudinal Study on Health and Aging", Metabolism, 61, pp.317~324 (2012)
- Lee WJ, "Relative handgrip strength is a simple indicator of cardiometabolic risk among middle-aged and older people : a nationwide population-based study in Taiwan", PLoS One, 11, pp.e0160876~ (2016)
- Attvall S, "Smoking induces insulin resistance : a potential link with the insulin resistance syndrome", J Intern Med, 233, pp.327~332 (1993)
- Bell RA, "Associations between alcohol consumption and insulin sensitivity and cardiovascular disease risk factors : the Insulin Resistance and Atherosclerosis Study", Diabetes Care, 23, pp.1630~1636 (2000)
- Bell LM, "Exercise alone reduces insulin resistance in obese children independently of changes in body composition", J Clin Endocrinol Metab, 92, pp.4230~4235 (2007)
- Zhan Y, "Socioeconomic status and metabolic syndrome in the general population of China : a crosssectional study", BMC Public Health, 12, pp.921~ (2012)
- Park SJ, "Sex differences in the relationship between socioeconomic status and metabolic syndrome : the Korean National Health and Nutrition Examination Survey", Diabetes Res Clin Pract, 96, pp.400~406 (2012)
- Tsao TS, "Enhanced insulin action due to targeted GLUT4 overexpression exclusively in muscle", Diabetes, 45, pp.28~36 (1996)
- Holten MK, "Strength training increases insulin-mediated glucose uptake, GLUT4content, and insulin signaling in skeletal muscle in patients with type 2 diabetes", Diabetes, 53, pp.294~305 (2004)
- Sumner AE, "Ethnic differences in the ability of triglyceride levels to identify insulin resistance", Atherosclerosis, 196, pp.696~703 (2008)
- Tai ES, "Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men", Diabetologia, 53, pp.757~767 (2010)