동결 건조된 리포솜의 안정화에 있어서 말토스의 영향

Abstract

Liposome powders were prepared by a freeze-drying method for the application to the field of drug car-rier. The effect of maltose as a liposome stabilizer was studied on the stability and the drug-loading eficiency of thefreeze-dried liposome powders. The particle size of liposomes before and after freeze-drying was determined to evaluatethe liposome stability. The drug-loading efficiency was measured by Fluorescence spectrophotometer using calcein asa model drug. When maltose was added after the preparation of the liposomes, the liposomes was stable, compared tothe addition of maltose, the liposome was stable for 30 daysat 4. 37oC, while the particle size of the liposome without maltose increased with time. The liposome showed relativelyhigh stability when the maltose/lipids molar ratio was 3 and 6.