Spectrophotometric Investigation of Oxidation of Cefpodoxime Proxetil by Permanganate in Alkaline Medium: A Kinetic Study
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
A Kinetics pathway of oxidation of Cefpodoxime Proxetil by permanganate in alkaline medium at a constant ionic strength has been studied spectrophotometrically. The reaction showed first order kinetics in permanganate ion concentration and an order less than unity in cefpodoxime acid and alkali concentrations. Increasing ionic strength of the medium increase the rate. The oxidation reaction proceeds via an alkali-permanganate species which forms a complex with cefpodoxime acid. The latter decomposes slowly, followed by a fast reaction between a free radical of cefpodoxime acid and another molecule of permanganate to give the products. Investigations of the reaction at different temperatures allowed the determination of activation parameters with respect to the slow step of proposed mechanism and fallows first order kinetics. The proposed mechanism and the derived rate laws are consistent with the observed kinetics.
Abstract
A Kinetics pathway of oxidation of Cefpodoxime Proxetil by permanganate in alkaline medium at a constant ionic strength has been studied spectrophotometrically. The reaction showed first order kinetics in permanganate ion concentration and an order less than unity in cefpodoxime acid and alkali concentrations. Increasing ionic strength of the medium increase the rate. The oxidation reaction proceeds via an alkali-permanganate species which forms a complex with cefpodoxime acid. The latter decomposes slowly, followed by a fast reaction between a free radical of cefpodoxime acid and another molecule of permanganate to give the products. Investigations of the reaction at different temperatures allowed the determination of activation parameters with respect to the slow step of proposed mechanism and fallows first order kinetics. The proposed mechanism and the derived rate laws are consistent with the observed kinetics.
참고문헌 (28)
- Borin, M. T, , Drugs, 42(13) (1991)
- Rodrıguez, J. C., , Farmaco, 58(363) (2003)
- Camus, F., , Chromatogr B., 565(383) (1994)
- Lovdahl, M. J, , J. Chromatogr B., 653(227) (1994)
- Yamana, T., , J. Pharm. Sci., 65(1563) (1976)
- Hovorka, S. W, , J. Pharm. Sci., 90(254) (2001)
- Shaabani, A., , Synth.Commun., 35(571) (2005)
- Caron, S., , Ripin, Chem.Rev., 106(2943) (2006)
- Lee, D. G., "Oxidation in Organic Chemistry Part D", pp.147~ (1982), Academic Press
- Simandi, L. I., "The Chemistry of Functional Groups" (1983), Wiley: Chichester
- Lee, D. G., "Phase Transfer Catalysis, New Chemistry, Catalysis and Applications", ACS Symposium Series, 326 (1987), American ChemicalSociety
- Fatiadi, A, , J. Synthesis, 106(85) (1987)
- Stewart, R., , Inorg. Chem., 36(2069) (1997)
- Panari, R. G., , J. Chem., 72(99), pp.107~ (1998)
- Bohn,A., , Tetrahedron Lett, 33(2795) (1992)
- Jeffery, G. H., "Vogel’s Text Book of Quantitative Chemical Analysis 5th ed.", pp.370~ (1996), ELBS Longman
- Carrington, A., "Structure and Reactivity of Oxyanions of Transition Metals. Part I TheManganese Oxy-anions", J. Chem. Soc., 337(3) (1956)
- K. S. Siddiqi, "Interaction of CFP with Metal ions: Complex Formation of CFP with Metal ion by Absorption and Fluorescence Spectrophotometery", 대한화학회지, 53(2), pp.152~158 (2009), 대한화학회
- Darwish, I. A, , Analytica Chimica Acta, 551(222) (2005)
- Timmanagoudar, P. L., , Transition. Met. Chem., 22(193) (1997)
- Nadimpalli, S., , A.Transition Met. Chem., 18(510) (1993)
- Thabaj, K. A., , Polyhedron, 26(4877) (2007)
- Panari, R. G., , J.Phys. Org. Chem., 11(448) (1998)
- Kini, A. K., , Transition.Met. Chem., 27(532) (2002)
- Devi, J, , Indian J. Chem., 34A(116) (1995)
- Weissberger, A, "Investigation ofrate and Mechanism of reaction In Techniques ofChemistry", pp.421~ (1974), Willey: Interscience Publication
- Rangappa, K. S, , J.Org. Chem., 63(531) (1998)
- Bugarcic, Z. D., , Dalton Trans., 2984 (2006)