Microwave-Assisted One-Pot Synthesis of Octahydroquinazolinone Derivatives Catalyzed by Thiamine Hydrochloride Under Solvent-free Condition
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Thiamine hydrochloride (VB1) has been used as an acid catalyst in organic synthesis. One pot three component Biginelli condensation of dimedone, urea/thiourea and substituted aromatic aldehydes catalyzed by 10 mol % of thiamine hydrochloride (VB1) in solvent free condition under microwave irradiation in good to excellent yields has been investigated. Utilization of microwave irradiation, simple reaction conditions, short reaction time, ease of product isolation, and purification makes this manipulation very interesting from an economic and environmental perspective.
Abstract
Thiamine hydrochloride (VB1) has been used as an acid catalyst in organic synthesis. One pot three component Biginelli condensation of dimedone, urea/thiourea and substituted aromatic aldehydes catalyzed by 10 mol % of thiamine hydrochloride (VB1) in solvent free condition under microwave irradiation in good to excellent yields has been investigated. Utilization of microwave irradiation, simple reaction conditions, short reaction time, ease of product isolation, and purification makes this manipulation very interesting from an economic and environmental perspective.
참고문헌 (24)
- Kidwai, M., , Eur. J. Med. Chem, 40, pp.816~ (2005)
- Yarim, M., , II Farmaco, 58, pp.17~ (2003)
- Yarim, M., , Arzneim-Forsch, 52, pp.27~ (2002)
- Hassani, Z., , Bio. Org. Med. Chem. Lett, 16, pp.4479~ (2006)
- Kantevari, S., , Arkivoc, xvi, pp.136~ (2006)
- Lin, H., , J. Mol. Catal. A: Chemical, 268, pp.221~ (2007)
- Hassani, Z., , Bioorg. Med. Chem. Letts, 16, pp.4479~ (2006)
- Niralwad, K. S., , J. Chin. Chem. Soc, 57, pp.1~ (2010)
- Tonkikh, N. N., , Chem. Heterocycl. Compds, 40, pp.43~ (2004)
- Loupy, A., "Microwaves in organic synthesis, 2nd ed" (2006), Wiley- VCH
- Varma, R. S., , Green Chemistry, 1, pp.43~ (1999)
- Yasuhara, A., , Chem.Pharm. Bull, 50, pp.143~ (2002)
- Amantini, D., , J. Org. Chem, 69, pp.2896~ (2004)
- Hiyama, T., , Pure & App. Chem, 66(7), pp.1471~ (1994)
- Sharma, R. K., , J. Org. Chem, 48(12), pp.2113~ (1983)
- Sun, H., , J. Am. Chem. Soc, 127, pp.2050~ (2005)
- Mandhane, P. G., "C.H.Tetrahedron Lett.2010", Tetrahedron Lett, 51, pp.1490~ (2010)
- Mandhane, P. G., , Tetrahedron Lett, 51, pp.3138~ (2010)
- Joshi, R. S., , Ultrason. Sonochem, 17, pp.298~ (2009)
- Joshi, R. S., , Chin. Chem. Lett, 21, pp.429~ (2010)
- Jadhav, G. R., , Chin. Chem. Lett, 20, pp.292~ (2009)
- Jadhav, G. R., , Chin. Chem. Lett, 20, pp.535~ (2009)
- Priyanka G. Mandhane, "Ammonium Metavanadate: A Mild and Efficient Catalyst for the Synthesis of Coumarins", Bulletin of the Korean Chemical Society, 30(12), pp.2969~2972 (2009), 대한화학회
- Falsone F. S., , Arikivoc, (II), pp.122~ (2001)