Synthesis and Antidiabetic Evaluation of Benzothiazole Derivatives
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
A novel series of benzothiazole derivatives were synthesized and assayed in vivo to investigate their hypoglycemic activity by streptozotocin-induced diebetic model in rat. These derivatives showed considerable biological efficacy when compared to glibenclamide, a potent and well known antidiabetic agent as a reference drug. All the compounds were effective, amongst them 3d showed more prominent activity at 100 mg/kg p.o. The experimental results are statistically significant at p<0.01 and p<0.05 level.
Abstract
A novel series of benzothiazole derivatives were synthesized and assayed in vivo to investigate their hypoglycemic activity by streptozotocin-induced diebetic model in rat. These derivatives showed considerable biological efficacy when compared to glibenclamide, a potent and well known antidiabetic agent as a reference drug. All the compounds were effective, amongst them 3d showed more prominent activity at 100 mg/kg p.o. The experimental results are statistically significant at p<0.01 and p<0.05 level.
참고문헌 (53)
- Geewananda, G. P, , J. Am. Chem. Soc, 110(14), pp.4856~ (1988)
- Geewananda, G. P, , Tetrahedron Lett, 30, pp.4359~ (1989)
- Gunawardana, G. P, , J. Org. Chem, 57(5), pp.523~ (1992)
- Carroll, A. R, , J. Org. Chem, 55(14), pp.4426~ (1990)
- Bryson, M, , Drugs, 52, pp.549~ (1996)
- Chopade, R. S, , Arch. Pharm. Pharm. Med. Chem, 8, pp.381~ (2002)
- Yogeeswari, P, , Eur. J. Med. Chem, 37, pp.231~ (2002)
- Yogeeswari, P, , J. Stables II, Farmaco, 60, pp.1~ (2005)
- Siddiqui, N, , Bioorg. Med. Chem. Lett, 17, pp.255~ (2007)
- Siddiqui, N, , Bioorg. Med. Chem. Lett, 17, pp.4178~ (2007)
- Hays, S. J, , J. Pharm. Sci, 83, pp.1425~ (1994)
- He, Y, , Neuropharmacology, 42, pp.199~ (2002)
- Gurupadayya, B. M, , Int. J. Heterocyclic Chem, 15, pp.169~ (2005)
- Sawhney, S. N, , Indian J. Chem, 16B, pp.605~ (1978)
- Foscolos, G, , Ann. Pharm. Fr, 35, pp.295~ (1977)
- Siddiqui, N, , Asian. J. Chem, 16, pp.1005~ (2004)
- Bensimon, G, , New Engl. J. Med, 330, pp.585~ (1994)
- Bensimon, G, , New Engl. J. Med, 330, pp.585~ (1994)
- Paget, C. J, , J. Med. Chem, 12, pp.1016~ (1969)
- Vicini, P, , Bioorg. Med. Chem, 11, pp.4785~ (2003)
- Caleta, I, , J. Med. Chem, 52, pp.1744~ (2009)
- Chung, Y, , Arch. Pharmacol. Res, 27, pp.893~ (2004)
- Yoshida, M, , Bioorg. Med. Chem. Lett, 15, pp.3328~ (2005)
- Bradshaw, T. D, , Curr. Med. Chem, 8, pp.203~ (2001)
- Chua, M. S, , J. Med. Chem, 42, pp.381~ (1999)
- O’Brien, S. E, , Org. Biomol. Chem, 1, pp.493~ (2003)
- Bradshaw, T. D, , Br. J. Cancer, 77, pp.745~ (1998)
- Kashiyama, E, , J. Med. Chem, 42, pp.4172~ (1999)
- Hutchinson, I, , J. Med. Chem, 44, pp.1446~ (2001)
- Shi, D. F, , J. Med. Chem, 39, pp.3375~ (1996)
- Lion, C. J, , Bioorg. Med. Chem. Lett, 16, pp.5005~ (2006)
- Mortimer, C. S, , J. Med. Chem., 49, pp.179~ (2006)
- Wells, G, , J. Med. Chem, 46, pp.532~ (2003)
- Hutchinson, I, , J. Med. Chem, 45, pp.744~ (2002)
- Khadse, B. G, , Indian J. Chem, Sec-B, pp.407~ (1993)
- Palmer, F. J, , J. Med. Chem, 14, pp.248~ (1971)
- Gurupadaiah, B. M, , Indian J. Heterocycl. Chem, 7, pp.213~ (1998)
- Gopkumar, P, , Indian J. Heterocycl. Chem, 11, pp.39~ (2001)
- Burger, A, , J. Med. Chem, 11, pp.270~ (1968)
- Jayachandran, E, , Indian Drugs, 40, pp.408~ (2003)
- Weekes, A. A, , Curr. Med. Chem, 16, pp.2430~ (2009)
- Henriksen, G, , J. Med. Chem, 50, pp.1087~ (2007)
- Mathis, C. A, , J. Med. Chem, 46, pp.2740~ (2003)
- Wang, X, , J. Med. Chem, 52, pp.170~ (2009)
- Suter, H, , Helv. Chim. Acta, 50, pp.1084~ (1967)
- Diaz, H. M, , Bioorg. Med. Chem. Lett, 18, pp.2871~ (2008)
- Nitta, A, , Bioorg. Med. Chem. Lett, 15, pp.5435~ (2008)
- Vazquez, G. N, , Bioorg. Med. Chem. Lett, 17, pp.3332~ (2009)
- Su, X, , Mol. Cell Endocrinol, 248, pp.214~ (2006)
- Barf, T, , J. Med. Chem, 45, pp.3813~ (2002)
- Fujieda, H, , Bioorg. Med. Chem. Lett, 17, pp.4351~ (2007)
- -2,4-thiazolidinediones as PPARγ Agonists, "Archives of Pharmacal Research", 2006, 394~399, pp.대한약학회
- Pattan, S. R, , Indian. J. Chem, 44B, pp.2404~ (2005)